Characteristics of patients with ADPKD and HV
| ADPKD (n=76) | HV (n=32) | p Value | |
|---|---|---|---|
| Age (years) | 50.96±15.59 | 49.53±7.32 | 0.47 |
| Female (%) | 43 (%56.57) | 20 (%62.50) | 0.35 |
| Male (%) | 33 (%43.43) | 12 (%37.50) | 0.45 |
| BMI (kg/m2) | 28.21±5.34 | 27.37±4.31 | 0.40 |
| SBP (mm Hg) | 128.17±15.17 | 111.97±13.21 | <0.001 |
| DBP (mm Hg) | 84.35±11.59 | 78.03±10.24 | 0.012 |
| Creatinine (mg/dL) | 1.77±1.16 | 0.88±0.12 | <0.001 |
| eGFR (mL/min/1.73 m2) | 57.24±33.80 | 90.15±20.71 | <0.001 |
| UPCR | 0.15 (0.05–1.91) | 0.06 (0.04–0.18) | <0.001 |
| Calcium (mg/dL) | 9.41±0.39 | 9.37±0.39 | 0.61 |
| Phosphate (mg/dL) | 3.51±0.77 | 3.28±0.67 | 0.16 |
| Ca×P (mg2/dL2) | 33.3±0.52 | 33.1±0.85 | 0.55 |
| iPTH (pg/mL) | 90 (30–1911) | 53 (31–62) | <0.001 |
| Albumin (g/dL) | 4.27±0.34 | 4.26±0.28 | 0.89 |
| 25(OH)D3 (ng/mL) | 27.02±11.56 | 62.13±18.37 | <0.001 |
| FGF-23 (pg/mL) | 166.69 (68.60–2431.37) | 82.14 (3.24–1452.86) | <0.001 |
| Soluble α-Klotho (ng/mL) | 2.92 (0.99–21.97) | 2.04 (0.95–19.98) | 0.001 |
| Hb (mg/dL) | 13.3±1.7 | 13.8±1.3 | 0.9 |
| ALP (U/l) | 71.45±27.23 | 76.25±16.36 | 0.35 |
25(OH)D3, 25-hydroxyvitamin D3; ADPKD, autosomal dominant polycystic kidney disease; ALP, alkaline phosphatase; BMI, body mass index; Ca, calcium; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FGF-23, fibroblast growth factor-23; Hb, haemoglobin; HV, Healthy volunteers; iPTH, intact parathyroid hormone; P, phosphate; SBP, systolic blood pressure; UPCR, urinary protein to creatinine ratio.