Association between ischemic stroke and matrix metalloproteinase-2 methylation level by sex
| CpG position/ methylation % | Men | Women | ||||||
|---|---|---|---|---|---|---|---|---|
| Stroke n=147 | Control n=121 | Crude p value | Adjusted p value | Stroke n=151 | Control n=137 | Crude p value | Adjusted p value | |
| Mean±SD | Mean±SD | Mean±SD | Mean±SD | |||||
| Site 1 | 1.81±0.98 | 2.14±1.13 | 0.012 | 0.064 | 1.94±1.06 | 2.12±1.10 | 0.153 | 0.253 |
| Site 2 | 3.61±1.99 | 4.21±2.34 | 0.024 | 0.121 | 3.89±1.95 | 4.27±2.25 | 0.121 | 0.245 |
| Site 3 | 4.08±1.97 | 4.73±2.18 | 0.011 | 0.135 | 4.38±1.94 | 4.59±2.00 | 0.354 | 0.453 |
| Site 4 | 3.43±1.77 | 3.95±2.24 | 0.034 | 0.130 | 3.75±1.89 | 3.97±1.98 | 0.341 | 0.464 |
| Site 5 | 1.82±0.83 | 2.25±1.31 | 0.001 | 0.011 | 2.02±0.91 | 2.25±1.10 | 0.051 | 0.061 |
| Site 6 | 3.30±1.79 | 3.92±2.33 | 0.014 | 0.175 | 3.56±1.76 | 3.82±1.97 | 0.238 | 0.352 |
| Site 7 | 2.62±1.15 | 3.04±1.48 | 0.010 | 0.059 | 2.77±1.19 | 3.01±1.35 | 0.109 | 0.210 |
| Site 8 | 4.33±2.25 | 4.88±2.45 | 0.056 | 0.266 | 4.59±2.21 | 5.06±2.32 | 0.079 | 0.092 |
| Average of all sites | 3.12±1.51 | 3.65±1.87 | 0.011 | 0.095 | 3.36±1.53 | 3.64±1.61 | 0.141 | 0.221 |
Adjusted p values were adjusted for age, hypertension, diabetes, hypercholesterolemia, and smoking status.
CpG, cytosine-guanine sites.