Table 1

The changes of inflammatory cells with heparin, simvastatin, or combined treatment

SalineHeparinSimvastatinHeparin+simvastatinp Value
Neutrophils
 3 days11.7±1.38.5±1.6*5.6±1.1*†4.0±0.6*†‡<0.0001
 7 days12.2±1.510.5±1.7*6.2±1.5*†2.5±0.6*†‡<0.0001
 14 days11.4±1.47.8±2.2*3.3±0.5*†1.1±0.6*†‡<0.0001
 p ValueNS<0.0001<0.0001<0.0001
Monocytes
 3 days5.9±0.65.7±1.13.8±0.7*†3.5±0.6*†<0.0001
 7 days6.7±0.67.0±1.03.9±1.1*†2.3±0.7*†‡<0.0001
 14 days7.5±0.75.0±1.3*2.2±0.4*†1.2±0.4*†‡<0.0001
 p Value<0.0001<0.0001<0.0001<0.0001
Lymphocytes
 3 days9.4±1.05.2±2.4*8.3±1.9†6.5±1.4*‡<0.0001
 7 days15.5±1.37.9±1.5*9.3±1.8*†4.6±1.6*†‡<0.0001
 14 days26.4±1.75.9±1.9*5.5±1.8*3.1±1.5*†‡<0.0001
 p Value<0.0001<0.0001<0.0001<0.0001

  • Data are expressed as mean±SE, n=4 per group.

  • *p Value <0.001 compared with saline control.

  • †p Value <0.001 compared with heparin treatment.

  • ‡p Value <0.001 compared with Simvastatin treatment.