Effects of GATA rare variants in demographic, clinical, and echocardiographic characteristics of patients with hypertrophic cardiomyopathy
| S | S+G | p Value | NS | NS+G | p Value | |
|---|---|---|---|---|---|---|
| BMI (kg/m2) | 26.8±5 | 27±4 | 0.80 | 27.1±5 | 26.4±2 | 0.73 |
| Family history (%) | ||||||
| Hypertrophic cardiomyopathy | 39 | 66.7 | 0.22 | 22.3 | 27.3 | 0.79 |
| Sudden cardiac death | 19.3 | 33.3 | 0.63 | 2.2 | 25 | 0.25 |
| Clinical symptoms (%) | ||||||
| Angina | 23.2 | 55.5 | 0.029 | 34.1 | 8.3 | 0.14 |
| Syncope | 15.78 | 11.11 | 0.72 | 18.60 | 8.3 | 0.50 |
| Dyspnea | 62.1 | 44.4 | 0.19 | 55.2 | 66.7 | 0.23 |
| Echocardiographic data | ||||||
| Interventricular septum (mm) | 20.9±6 | 20.7±5 | 0.98 | 19±5 | 21±3 | 0.11 |
| Posterior wall (mm) | 14.9±5 | 12.9±3 | 0.40 | 14±3 | 16±4 | 0.019 |
| LVOTO (%) | 41.1 | 55.5 | 0.37 | 47.7 | 33.3 | 0.61 |
Quantitative variables are shown as mean±SD.
S, patients carrying sarcomeric mutation; G, patients carrying GATA variant; NS, patients not carrying sarcomeric mutation; p value was obtained by multivariate analysis after adjusting by gender and age.
BMI, body mass index; LVOTO, left ventricular outflow tract obstruction.