Combination drug inhalers used for maintenance treatment of COPD
| Drug 1+drug 2 | DI (µg) | DF | Type DD | DD name | Name | |
|---|---|---|---|---|---|---|
| LABA+LAMA | ||||||
| Indacterol | Glycopyrronium | 110/50 | Once a day | DP | Ultibro Breezhaler | QVQ149 |
| Vilanterol | Umeclidinium | 25/62.5 | Once a day | DP | Ellipta | Anoro |
| Olodaterol | Tiotropium | 3.5/2.5 | Once a day | SDM | Respimat | Stiolto |
| Formoterol | Aclidinium | 12/400 | two times a day | DP | Genuair | Duaklir |
| Formoterol | Glycopyrrolate | 4.8/9 | two times a day | MDI | Bevespi Aerosphere | |
| SABA+SAMA | ||||||
| Albuterol | Ipratropium | 2.5/0.5 (mg) | Every 6 hours | Neb | DuoNeb | |
| Albuterol | Ipratropium | 0.1/0.33 (mg) | Every 6 hours | SDM | Respimat | Combivent |
| LABA +ICS | ||||||
| Vilanterol | Fluticasone F | 25/100 | Once a day | DP | Ellipta | Breo |
| Formoterol | Budesonide | 4.5/160 or 80 | Two times a day | MDI | Symbicort | |
| Formoterol | Budesonide | 6612/100,200,400 | Two times a day | DP | Turbuhaler | Symbicort |
| Formoterol | Mometasone | 5/100 or 200 | Two times a day | MDI | DuleraA | |
| Salmeterol | Fluticasone P | 50/100,250,500 | Two times a day | DP | Diskus | Advair |
| Salmeterol | Fluticasone P | 21/45,115,230 | Two times a day | MDI | Advair HFAA | |
A, approved for asthma indication only, all others approved for COPD or COPD+asthma; COPD, chronic obstructive pulmonary disease; DF, dose frequency; DI, dose per inhalation; DP, dry powder; F, furoate; ICS, inhaled corticosteroid; LABA, long-acting β-2 agonist; LAMA, long-acting muscarinic antagonist; MDI, metered dose inhaler; Neb, nebulization; P, propionate; SABA, short-acting β-2 agonist; SAMA, short-acting muscarinic antagonist; SDM, spring driven mist; Type DD, type of delivery device.