Comparison of biochemical and demographic data among CKD groups
| Variables | CKD stage 3 (n=33) | CKD stage 4 (n=48) | CKD stage 5 (n=31) | p Value |
| Age | 52.2±13.4 | 49.8±13.5 | 53.3±12.7 | 0.502 |
| Male | 20 (60.6%) | 26 (54.2%) | 16 (51.6%) | 0.752 |
| Diabetes | 9 (27.3%) | 10 (20.8%) | 6 (19.4%) | 0.710 |
| Hypertension | 14 (42.4%) | 22 (45.8%) | 23 (74.2%) | 0.026 |
| Vitamin D supplement | 18 (54.5%) | 32 (66.7%) | 19 (61.3%) | 0.544 |
| eGFR (mL/min/1.73 m2) | 38.2±7.3 | 22.1±6.3 | 10.8±2.2 | <0.001 |
| Ca (mmol/L) | 2.21±0.15 | 2.09±0.14 | 2.04±0.15 | 0.002 |
| P (mmol/L) | 1.23±0.21 | 1.46±0.31 | 1.48±0.34 | 0.008 |
| HGB (g/L) | 118.4±22.1 | 103.3±24.4 | 94.5±12.0 | 0.031 |
| iPTH (pg/mL) | 143.5 (67.8, 195.3) | 298.4 (204.5, 376.5) | 488.6 (400.5, 659.6) | <0.001 |
| Klotho (ng/mL) | 3.62 (1.24, 7.01) | 2.35 (1.59, 2.98) | 1.01 (1.00, 1.65) | <0.001 |
| FGF23 (pg/mL) | 387.4 (320.3, 454.7) | 512.7 (441.3, 610.3) | 760.4 (618.5, 874.2) | <0.001 |
Data are presented as mean±SD for normally distributed variables, otherwise median with 25th–75th percentile.
Ca, calcium; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; FGF23, fibroblast growth factor 23; HGB, hemoglobin; iPTH, intact parathyroid hormone; Scr, serum creatinine.