Protein C | Protein S | Free S | Antithrombin III | Lp(a) | Lupus anticoagulant | |
Abnormal range | <73% | <63% | <66% | <80 | ≥35 | positive |
19 TT cases | 2/13 (15%) | 0/11 (0%) | 0/9 (0%) | 1/13 (8%) | 6/11 (55%) | 5/15 (33%) |
110 VTE-controls | 21/105 (20%) NS | 12/104 (12%) NS | 24/85 (28%) NS | 3/102 (3%) NS | 12/71 (17%) P=0.012 | 4/91 (4%) P=0.003 |
*Dated cut point for RAPC low: < 2.0 (before January 1, 1999); < 1.94 (January 1, 19 99 to January 23, 2001); < 2.2 (January 23, 2001 to March 25, 2004); < 2.1 (after March 25, 2004).
†Dated cut point for IgG high: ≥ 23 GPL (anticardiolipin G units) (before October 31, 2012); ≥ 15 (after November 1, 12).
‡Dated cut point for IgM high: ≥ 10 MPL (anticardiolipin M units) (before April 30, 2012); ≥ 13 (after May 1, 12).
§Dated cut point for homocysteine high: ≥ 13.5 μmol/L (before March 20, 2005); ≥ 12 (March 21, 2005 to March 27, 2006); ≥ 10.4 (March 28, 2006 to April 14, 2008); ≥ 11.4 (April 15, 2008 to November 14, 2008); ≥ 15 (November 15, 2008 to December 2, 2014); ≥ 10.4 (after December 3, 2014).
ACLA, anticardiolipin antibody; CC, wild type normal; Factor V, Factor V Leiden mutation; Lp(a), lipoprotein (a); MTHFR C677T, A1298C, methylenetetrahydrofolate reductore; PAIG, plasminogen activator inhibitor gene; PAI-1, plasminogen activator inhibitor activity; Pro C, protein C antigen; Pro S, protein S antigen; PTG, prothrombin gene mutation; RAPC, resistance to activated protein C; TC, heterozygote mutant; TT, homozygous mutant; VTE, venous thromboembolism .