Comparison between controls and FCH subjects with and without insulin resistance
| Control (n=36) | FCH non-IR (n=19) | FCH IR (n=17) | p Value | |
| MPO (ng/mL) | 38.9±158.2 | 61.8±215.6 | 127.5±255.5 | 0.184*, 0.03†, 0.009‡ |
| PAI-1 (ng/mL) | 41.4±33.1 | 49.4±33.6 | 99.5±55.3 | 0.284*, <0.001†, 0.016‡ |
| IMT (mm) | 0.47±0.12 | 0.53±0.11 | 0.57±0.1 | 0.115*, 0.017†, 0.0519‡ |
Values expressed as mean±SD.
FCH, familial combined hyperlipidemia; IMT, intima media thickness; IR, insulin resistance (homeostasis model assessment ≥3.2); MPO, myeloperoxidase; PAI-1, plasminogen activator inhibitor type-1.
*Control versus FCH without IR.
†Control versus FCH with IR.
‡FCH without IR versus FHC with IR.