Studies evaluating the effects of methylphenidate on heart rate and blood pressure
| Author, year | Age (years) | Number of patients analysed | Measurements of cardiovascular risk | Follow-up period | Results* |
|---|---|---|---|---|---|
| Arcieri et al., 2012 | 6–18 | 351 | BP, HR, ECG | Monthly for 24 months | Increase in HR (2.1 bpm) at 6 months, decrease in diastBP (−3.9 mm Hg) and HR (−3.8 bpm) at 24 months |
| Hammerness et al., 2009 | 12–18 | 114 | BP, HR, ECG, metabolic panel | Weekly for 6 months | Increase in systBP (2.1 mm Hg) and HR (4.3 bpm) at 6 weeks and syst BP (1.9 mm Hg) and HR (0.6 bpm) at 6 months |
| Kratochvil et al., 2002 | 7–15 | 44 | BP, HR, weight | Weekly for 10 weeks | Increase in systBP (2.95 mm Hg) and diastBP, (3.35 mm Hg), and HR (5.56 bpm) at 10 weeks |
| Wilens et al., 2004 | 6–13 | 432 | BP, HR, weight | Monthly for 1 year | Increase in systBP (1.6 mm Hg), diastBP, (1.4 mm Hg) and HR (1.1 bpm) at 12 months |
| Lee et al., 2013 | 12–18 | 55 | BP, HR, weight | Bi-monthly for 3 months | Increase in systBP (4.27 mm Hg), diastBP (5.87 mm Hg), and HR (3.8 bpm) at 12 weeks |
| Yildiz et al., 2010 | 8–14 | 11 | BP, HR, weight | Endpoint at 12 weeks | Not statistically significant due to small sample size. |
*Only statistically significant changes are reported