Characteristics of the individuals
| Lean | Obese | Two-way analysis of variance (p values) | |||||
| Males | Females | Males | Females | Sex | Group | Sex*group | |
| n | 5 | 5 | 5 | 5 | |||
| Age (years) | 35.2±8.5 | 31.1±5.0 | 37.8±3.1 | 34.0±10.6 | 0.25 | 0.42 | 0.97 |
| Body weight (kg) | 67.5±5.2 | 55.4±3.9 | 100.8±10.5 | 83.5±7.4 | <0.001 | <0.0001 | 0.43 |
| BMI (kg/m2) | 22.4±1.0 | 21.7±1.2 | 32.5±1.5 | 32.3±1.6 | 0.46 | <0.0001 | 0.76 |
| Fasting | |||||||
| Glucose (mg/dL) | 89.5±5.7 | 88.8±3.0 | 94.2±2.4 | 90.8±2.9 | 0.23 | 0.06 | 0.44 |
| Insulin (mU/L) | 5.8±2.3 | 4.2±2.0 | 9.5±2.5 | 14.9±7.2 | 0.30 | <0.01 | 0.08 |
| Lactate (mmol/L) | 1.16±0.27 | 0.84±0.33 | 1.54±0.14 | 1.21±0.41 | <0.05 | <0.05 | 0.97 |
| Triglycerides (mg/dL) | 112±52 | 67±50 | 113±56 | 97±39 | 0.20 | 0.49 | 0.52 |
| HOMA | 1.26±0.50 | 0.94±0.48 | 2.21±0.64 | 3.33±1.52 | 0.34 | <0.001 | 0.09 |
| OGTT | |||||||
| 2 hour glucose (mg/dL) | 107.3±16.1 | 111.6±22.5 | 144.2±22.9 | 119.0±32.1 | 0.35 | 0.06 | 0.19 |
| 2 hour insulin (mU/L) | 45.1±25.2 | 46.6±47.3 | 75.5±31.5 | 101.2±50.0 | 0.46 | <0.05 | 0.51 |
| Matsuda index | 5.70±2.99 | 8.08±4.22 | 2.96±0.95 | 2.19±0.45 | 0.50 | <0.01 | 0.20 |
| OGIS-2h | 430.7±49.4 | 428.9±72.3 | 340.9±40.6 | 351.1±43.3 | 0.87 | <0.01 | 0.81 |
| MOTS-c (ng/mL) | 0.54±0.21 | 0.42±0.08 | 0.49±0.11 | 0.55±0.19 | 0.71 | 0.60 | 0.22 |
Data are means±SD.
BMI, body mass index; HOMA, homeostatic model assessment; OGTT, oral glucose tolerance test; OGIS, oral glucose insulin sensitivity.