| Year Published | First Author | Study Location | Number of Patients | Number of Recurrent Cases | Time Between First and Second Episode | Factors During Initial Episode Associated with Increased Risk of Recurrence |
|---|---|---|---|---|---|---|
| 2012 | Chahal* | Canada | 1010 | 17 in 16 patients (1.7%) | Average: 1.5 years | Longer duration of fever before diagnosis (p=0.01) and total duration of fever (p=0.02) Lower median albumin (p=0.03) Higher white blood cell count (p=0.05) |
| 2001 | Hirata* | Japan | 10 679 | 217 (2.0%) | Range: 2–11 months | Presence of cardiac sequelae within 1 year (hazard ratio: 1.77–4.39) |
| 2015 | Maddox | United States | 5557 | 97 (1.7%) | Average: 22.5 months | Coronary artery abnormality (p=0.01) Atypical KD cases (p=0.006) |
| 2015 | Maddox | United States | 13 874 | 483 (3.5%) | Not Reported | Being Asian/Pacific Islander (hazard ratio: 1.4–3.7) Rash (p=0.03) and cervical lymphadenopathy (p<0.001) Coronary artery abnormailty (p=0.003) Atypical KD (p=0.01) |
| 2017 | Sudo | Japan | 81 310 | 1842 (2.3%) | Range: within 2 years | Being male (hazard ratio: 1.01–1.21) Steroid therapy (hazard ratio: 1.14–1.70) Resistance to IVIG (hazard ratio: 1.18–1.67) |
| 2013 | Yang* | China | 1173 | 22 (1.9%) | Average: 12 months | Being female (p=0.026) Longer duration of fever before IVIG treatment (p<0.001) Lower hemoglobin level (p<0.001) Higher ALT (p=0.032) and AST (P Coronary artery abnormality (p=0.035) |
*Studies that included laboratory values as risk factors for recurrence.