Association of IGD and Changes in Brain Matter Structure and Behavioral Outcomes
| First Author, Year Published | IGD Subjects (n) vs. Healthy Controls (n) | Changes in Structure | Behavioral or Mood Outcomes | |
|---|---|---|---|---|
| Seok JW, 2018 | 20 vs 20 | GMD increase in left caudate (P | Internet addiction scores (severity) were positively associated with depression scores (p<0.001;) impulsiveness scores (p<0.001). | |
| Choi J, 2017 | 22 vs 24 | GMD lower DLPFC in IGD subjects, P | In IGD group: Lower DLPFC correlated with depression (p=0.001) | |
| Lee D, 2018 | 45 vs 35 | GMV smaller in the singulate and orbitofrontal cortex w/IGD (P | IGD group with higher motor impulsivity: p<0.001 | |
| Weng CB, 2013 | 17 vs 17 | GMV decreased in right orbitofrontal cortex and bilateral insula (P | Barret Impuliveness Scale higher in patients with IGD (p<0.05) | |
| Wang H, 2015 | 28 vs 28 | GMV decreased in the bilateral anterior cingulate cortex, precuneus motor area, superior parietal cortex, left DLPFC, left insula and bilateral cerebellum in IGD subjects, (p<0.05) | Stroop task: the IGD group committed more errors than the control group during the incongruent condition (p<0.05) | |
| Cai C, 2016 | 27 vs 30 | GMV increase in the right caudate and right nucleus accumbens (NAc) of subjects with IGD (p<0.05) | Stroop task incongruent errors higher in IGD compared to controls (p<0.05), | |
| Yuan K, 2016 | 43 vs 40 | 15–23 | Increased volume of right caudate and nucleus accumbens (NAc) in subjects with IGD (p<0.05) | Stroop task incongruent errors higher in IGD compared to controls (p<0.05) |
GMD=Grey Matter Density, GMV=Grey Matter Volume, DLPFC=dorsolateral prefrontal cortex (DLPFC)