A comparison of observed minus expected outcomes in relation to cause-specific mortality (data sourced from Ridker et al 7)
| Cause of death | Deaths in placebo* (n=3344 total) | Death in treated (n=6717 total) | Expected deaths† | Observed-expected (difference [%]) |
| Lung cancer | 38 | 39 | 77 | −38 (−49) |
| Other cancers | 43 | 76 | 86 | −10 (−12) |
| Sepsis | 23 | 78 | 46 | +32 (+70) |
| Cardiovascular | 182 | 319 | 366 | −47 (−13) |
| Other/unknown | 89 | 193 | 178 | +15 (+8) |
| Total | 375 | 705 | 753 | −48 |
†The absolute number of expected deaths in the treated arm were calculated according to deaths in the placebo arm*. These were estimated to be approximately twofold that in the placebo arm.7