Arterial thromboembolic events in transfusion-naïve thalassemia and non-thalassemia groups
| Thalassemia n=2356 | Non-thalassemia n=9424 | Crude HR (95% CI) | Adjusted HR (95% CI)† | |
| Arterial thromboembolic event‡ | 177 (7.5) | 485 (5.2) | 1.52 (1.28 to 1.80)*** | 1.28 (1.07 to 1.52)* |
| Cerebrovascular ischemic event | 49 (2.1) | 169 (1.8) | 1.18 (0.86 to 1.62) | 0.97 (0.70 to 1.34) |
| Arterial embolism/thrombosis | 6 (0.3) | 10 (0.1) | 2.45 (0.89 to 6.73) | 1.95 (0.69 to 5.51) |
| Peripheral embolism | 12 (0.5) | 40 (0.4) | 1.22 (0.64 to 2.33) | 0.96 (0.50 to 1.84) |
| Myocardial infarction | 8 (0.3) | 22 (0.2) | 1.48 (0.66 to 3.33) | 0.97 (0.43 to 2.20) |
| Myocardial ischemia | 113 (4.8) | 269 (2.9) | 1.74 (1.39 to 2.16)*** | 1.41 (1.13 to 1.76)* |
| Angina pectoris | 42 (1.8) | 106 (1.1) | 1.62 (1.13 to 2.32)* | 1.32 (0.92 to 1.90) |
*p<0.05, **p<0.001, ***p<0.0001.
†Model adjusted for socioeconomic status, urbanization level, comorbidities at significance in an univariate model.
‡including cerebrovascular ischemic event, arterial embolism/thrombosis, peripheral embolism, myocardial infarction, myocardial ischemia, angina pectoris.