Baseline risk factor profile, anthropometric, routine laboratory parameters and correlations
| n/% of population/ mean±SD | suPAR (pg/mL) | H-FABP (ng/mL) | sST2 (pg/mL) | |
| Hypertension | 23/32.4 | |||
| Dyslipidemia | 19/26.8 | |||
| Diabetes mellitus | 1/1.4 | |||
| Overweight/adipositas | 46/65.8 | |||
| Ex-smoking | 30/42.3 | |||
| Smoking | 12/16.9 | |||
| Known CHD/stroke | 14/19.7 | |||
| Positive family anamnesis | 29/40.8 | |||
| Alcohol (units/wk) | 3.0±3.9 | 0.006/0.955 | 0.052/0.619 | 0.177/0.092 |
| Age (y) | 48.9±6.9 | 0.216/0.032 | −0.018/0.858 | 0.065/0.529 |
| BMI (kg/m2) | 27.6±4.3 | −0.079/0.440 | 0.259/0.010 | 0.214/0.036 |
| Body water (%) | 52.4±5.8 | 0.008/0.940 | −0.279/0.005 | 0.148/0.150 |
| Body fat (%) | 29.5±9.9 | 0.013/0.901 | 0.274/0.006 | −0.193/0.059 |
| Body muscle (%) | 35.1±4.2 | 0.016/0.874 | −0.052/0.608 | 0.337/0.001 |
| SBP (mm Hg) | 132±11 | 0.061/0.552 | 0.106/0.302 | 0.167/0.105 |
| DBP (mm Hg) | 78±7 | 0.024/0.818 | 0.039/0.708 | 0.142/0.171 |
| Performance 1 (%) | 103.8±18.6 | −0.060/0.555 | −0.280/0.005 | 0.104/0.312 |
| Performance 2 (%) | 115.9±19.0 | −0.013/0.900 | −0.319/0.001 | 0.028/0.788 |
| Performance gain (%) | 12.1±6.3 | 0.026/0.810 | −0.074/0.469 | −0.099/0.336 |
| Moderate intensity (min/mo) | 1248±940 | 0.052/0.637 | −0.043/0.694 | −0.052/0.641 |
| Vigorous intensity (min/mo) | 298±352 | −0.058/0.596 | −0.067/0.542 | <0.001/0.994 |
| Erythrocytes (x10^12/L) | 4.8±0.4 | 0.033/0.748 | 0.204/0.045 | 0.322/0.001 |
| Haemoglobin (g/L) | 142±13 | 0.018/0.861 | 0.237/0.020 | 0.403/<0.001 |
| Haematocrit (%) | 40.1±3.3 | 0.020/0.847 | 0.231/0.023 | 0.394/<0.001 |
| Thrombocytes (x10^9/L) | 243±51 | −0.030/0.771 | 0.002/0.984 | −0.160/0.121 |
| Leukocytes (x10^9/L) | 6.4±1.5 | −0.111/0.279 | 0.076/0.459 | 0.027/0.797 |
| Na (mmol/L) | 141±2 | 0.001/0.996 | −0.222/0.029 | 0.122/0.240 |
| K (mmol/L) | 4.2±0.3 | −0.205/0.044 | −0.167/0.102 | −0.162/0.116 |
| Cl (mmol/L) | 101±2 | −0.093/0.365 | −0.205/0.044 | −0.001/0.992 |
| Ca (mmol/L) | 2.3±0.1 | 0.101/0.324 | 0.138/0.177 | 0.079/0.448 |
| Phosphate (mmol/L) | 1.1±0.1 | −0.151/0.139 | −0.238/0.019 | −0.017/0.868 |
| Mg (mmol/L) | 0.85±0.06 | −0.102/0.321 | 0.087/0.398 | 0.080/0.442 |
| Creatinine (mg/dL) | 0.9±0.2 | 0.103/0.316 | 0.161/0.115 | 0.417/<0.001 |
| BUN (mg/dL) | 16±17 | 0.066/0.522 | 0.054/0.602 | 0.244/0.017 |
| Uric acid (md/dL) | 5.2±1.5 | 0.021/0.836 | 0.223/0.028 | 0.338/0.001 |
| Lipase (U/L) | 40±17 | −0.014/0.892 | −0.066/0.518 | −0.018/0.861 |
| Cholinesterase (kU/L) | 8.3±1.7 | −0.131/0.200 | 0.256/0.011 | 0.357/<0.001 |
| Alkaline phosphatase (U/L) | 64±41 | −0.111/0.279 | 0.124/0.227 | 0.229/0.025 |
| ASAT (U/L) | 25±8 | −0.009/0.928 | 0.177/0.083 | 0.432/<0.001 |
| ALAT (U/L) | 27±12 | −0.089/0.388 | 0.162/0.113 | 0.494/<0.001 |
| Gamma-GT (U/L) | 31±49 | 0.057/0.581 | 0.298/0.003 | 0.317/0.002 |
| LDH (U/L) | 173±25 | 0.059/0.564 | 0.196/0.054 | 0.106/0.309 |
| Triglycerides (mg/dL) | 133±82 | 0.089/0.386 | 0.356/<0.001 | 0.146/0.157 |
| Cholesterol (mg/dL) | 201±37 | 0.065/0.527 | 0.209/0.040 | 0.005/0.960 |
| HDL-cholesterol (mg/dL) | 58±18 | −0.041/0.690 | −0.210/0.039 | −0.206/0.045 |
| LDL-cholesterol (mg/dL) | 117±34 | 0.066/0.522 | 0.243/0.017 | 0.053/0.609 |
| Apolipoprotein A1 (mg/dL) | 156±29 | 0.015/0.885 | −0.054/0.601 | −0.191/0.064 |
| Apolipoprotein B (mg/dL) | 103±26 | 0.089/0.387 | 0.355/<0.001 | 0.078/0.451 |
| proBNP (pg/mL) | 44±42 | 0.084/0.412 | 0.008/0.937 | −0.108/0.298 |
| HbA1c (rel%) | 5.3±0.6 | 0.119/0.246 | 0.029/0.781 | −0.014/0.889 |
| hsCRP (mg/dL) | 0.19±0.18 | 0.202/0.048 | 0.275/0.006 | 0.040/0.702 |
| IL-6 (pg/mL) | 2.6±1.6 | 0.047/0.646 | 0.166/0.104 | 0.098/0.343 |
The table shows first, the cardiovascular risk factor profile, anthropometric data and lab analysis at baseline of the subjects who had a performance gain >2.9% and second, the correlation coefficient and significance of the correlation between suPAR, H-FABP and sST2 with anthropometric and routine laboratory parameters of all subjects who completed the study.
ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; BMI, body mass index; BNP, brain natriuretic peptide; BUN, blood urea nitrogen; Cl, chloride; Ca, calcium; CHD, chronic heart disease; DBP, diastolic blood pressure; GT, glutamyl transferase; HDL, high-density lipoprotein; H-FABP, heart-type fatty acid-binding protein; HR, heart rate; hsCRP, high-sensitivity C-reactive protein; IL, interleukin; K, potassium; LDH, lactate dehydrogenase; LDL, low-density lipoprotein; Mg, magnesium; Na, sodium; SBP, systolic blood pressure; sST2, soluble isoform of suppression of tumorigenicity 2; suPAR, soluble urokinase-type plasminogen activator receptor.