Table 4

Signs and Symptoms of Hypogonadism: prenatal vs. pre-pubertal vs. post-pubertal, primary vs. secondary

1st Trimester Gestational Life 3rd Trimester gestational life, mini-puberty Prepuberty Postpuberty
Primary HypogonadismSecondary HypogonadismPrimary HypogonadismSecondary Hypogonadism
Ambiguous genitalia+
Micropenis, Small testes, cryptorchidism+
Small Phallus++––
Small Testes++++++/-
High Pitch Voice++––
Eunuchoid Proportion++––
Recession Scalp Hairline––++
Chest/Facial Hair––+/-+/-
Gynecomastia++/-++/-
Low Muscle Mass+++/-+/-
Low Libido++++
Low Energy++++