Risk stratification of PH patients
| 1-year mortality prognosis factors | Low risk (<5%) | Intermediate risk (5%–10%) | High risk (>10%) |
| Clinical right heart failure | Absent | Absent | Present |
| Symptom progression | No | Slow | Rapid |
| Syncope | No | Occasional syncope with heavy exercise or orthostatic change | Repeated syncope, especially at rest |
| WHO Functional Class | I and III | III | IV |
| 6MWD (m) | 440 | 165–440 | <165 |
| Cardiopulmonary exercise testing | Peak VO2 >15 mL/min/kg (>65% pred) VE/VCO2 slope <36 | Peak VO2 11–15 mL/min/kg (35%–65% pred) VE/VCO2 slope 36–44.9 | Peak VO2 <11 mL/min/kg (<35% pred) VE/VCO2 slope >45 |
| NT-proBNP (ng/L) | <300 | 300–1400 | 1400 |
| Imaging (echocardiography and/or cardiac MRI) | RA area <18 cm2
No pericardial effusion | RA area 18–26 cm2
Minimal pericardial effusion | RA area >26 cm2
Pericardial effusion |
| Hemodynamics | RAP <8 mm Hg CI >2.5 L/min/m2 SvO2 >65% | RAP 8–14 mm Hg CI 2.0–2.4 L/min/m2 SvO2 60%–65% | RAP >14 mm Hg CI <2.0 L/min/m2 SvO2 <60% |