Baseline characteristics in 1:1 matched pairs of patients with fracture and without fracture
| Subjects without fracture (n=58) | Subjects with fracture (n=58) | P value | |
| Age (years), mean±SD | 63.7±6.8 | 64.3±6.6 | 0.660 |
| Weight (kg), mean±SD | 58.5±6.9 | 57.5±7.3 | 0.460 |
| Height (cm), mean±SD | 155.3±4.9 | 154.4±5.7 | 0.374 |
| BMI (kg/m2), mean±SD | 24.3±2.8 | 24.1±2.9 | 0.820 |
| Exercise ≥30 min/day, n (%) | 22 (37.9%) | 21 (36.2%) | >0.999 |
| Current smoker, n (%) | 1 (1.7%) | 0 (0.0%) | >0.999 |
| Alcohol intake ≥3 U/day, n (%) | 1 (1.7%) | 1 (1.7%) | >0.999 |
| Parental history of hip fracture, n (%) | 5 (8.6%) | 6 (10.3%) | >0.999 |
| FN-BMD (g/cm2), mean±SD | 0.787±0.112 | 0.736±0.109 | 0.013 |
| Corrected calcium (mg/dL)*, mean±SD | 8.8±0.5 | 9.0±0.4 | 0.185 |
| Phosphorus (mg/dL), mean±SD | 3.8±0.4 | 3.7±0.37 | 0.096 |
| S1P levels (pmol/mL), mean (95% CI) | |||
| Total S1P | 1030.3 (965.5–1095.2) | 1123.9 (1059.1–1188.8) | 0.046 |
| Albumin-bound S1P | 584.8 (542.8–626.4) | 651.9 (610.1–693.8) | 0.026 |
| HDL-bound S1P | 377.5 (345.1–409.9) | 409.3 (377.0–441.7) | 0.171 |
| LDL-bound S1P | 59.4 b(52.3–66.4) | 67.6 (60.5–74.6) | 0.104 |
Patients with fracture and without fracture were matched for age (±1.0 years) and BMI (±1.0 kg/m2).
All values are the mean±SD unless otherwise specified.
Boldface values are statistically significant.
*Corrected calcium concentration (mg/dL)=total calcium concentration (mg/dL)+0.8×[4.0 g/dL−serum albumin concentration (g/dL)].
BMD, bone mineral density; BMI, body mass index; FN-BMD, BMD at femur neck; HDL, high-density lipoprotein; LDL, low-density lipoprotein; S1P, sphingosine 1-phosphate.