Baseline characteristics, laboratory data and medications
| Patients (n=36) | Controls (n=27) | P value | |
| Baseline characteristics | |||
| Mean age (years) | 63.17±10.18 | 61.33±8.73 | 0.455 |
| Males, n (%) | 18 (50) | 12 (44) | 0.662 |
| Body mass index (kg/m2) | 28.38±5.13 | 28.91±4.97 | 0.682 |
| Hypertension, n (%) | 17 (47) | 9 (33) | 0.268 |
| Diabetes mellitus, n (%) | – | 14 (39) | 0.0001 |
| Smoking, n (%) | 3 (8) | 5 (19) | 0.272 |
| Systolic blood pressure (mm Hg) | 119.89±13.44 | 117.37±13.57 | 0.466 |
| Diastolic blood pressure (mm Hg) | 76.72±10.56 | 73.48±8.73 | 0.200 |
| Heart rate (beats/min) | 74.58±13.24 | 70.78±13.29 | 0.177 |
| Atrial fibrillation, n (%) | 10 (28) | – | 0.003 |
| LVEDD (mm) | 60.86±5.56 | 46.19±3.78 | <0.001 |
| LVESD (mm) | 49.11±6.40 | 29.04±3.03 | <0.001 |
| LVEF (%) | 27.27±5.23 | 60.17±3.21 | <0.001 |
| Laboratory findings | |||
| FPG (mg/dL) | 115.33±28.64 | 95.44±10.57 | 0.002 |
| Creatinine (mg/dL) | 0.96±0.16 | 0.72±0.10 | <0.001 |
| GFR (mL/min/m2) | 75.15±13.77 | 89.04±13.69 | <0.001 |
| Sodium (mEq/L) | 139.22±3.46 | 140.74±1.81 | 0.028 |
| T-chol (mg/dL) | 188.78±46.34 | 197.11±39.71 | 0.456 |
| TG (mg/dL) | 163.64±77.40 | 117.41±64.47 | 0.002 |
| LDL-C (mg/dL) | 110.17±31.27 | 118.56±30.65 | 0.292 |
| HDL-C (mg/dL) | 40.61±7.27 | 54.85±13.43 | <0.001 |
| Hemoglobin (g/L) | 137.00±13.00 | 142.50±13.30 | 0.08 |
| WBC (cells/μL) | 9.07±2.07 | 6.6±1.46 | <0.001 |
| Albumin (g/dL) | 4.27±0.26 | 4.56±0.25 | <0.001 |
| NT-proBNP (pg/mL) | 595.31±428.11 | 78.13±30.47 | <0.001 |
| Chitotriosidase (ng/mL) | 931.25±461.39 | 232.79±61.28 | <0.001 |
| Medication, n (%) | |||
| ACE inhibitor/ARB | 27 (75) | 8 (30) | <0.001 |
| Beta-blockers | 32 (89) | 2 (7) | <0.001 |
| Statins | 13 (36) | 1 (4) | 0.002 |
| Loop diüretics | 23 (64) | – | <0.001 |
| Aldosterone antagonist | 19 (53) | – | <0.001 |
| Antiplatelet agents | 34 (94) | 5 (19) | <0.001 |
| Digoxine | 9 (25) | – | <0.001 |
ACE, angiotensin-converting enzyme; ; ARB, angiotensin receptor blocker; FPG, fasting plasma glucose; GFR, glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LVEDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; NT-proBNP, N-terminal pro hormone brain natriuretic peptide; T-chol, total cholesterol; TG, triglycerides; WBC, white blood cells.