Table 3

Daily insulin doses requirements by metabolic control subgroups in T1D using glargine U300 or degludec

	HbA1c ≤7% (IGla: 65 P; IDeg: 48 P)		HbA1c 7.1%–8% (IGla: 69 P; IDeg: 82 P)		HbA1c ≥8% (IGla: 53 P; IDeg: 95 P)
		P value		P value		P value
Basal insulin
Unit/day
IGla-300	25.8±13.4	0.781	30.8±15.7	0.780	35.1±13.8	0.779
IDeg	26.6±16.8	0.781	31.6±19.0	0.780	35.8±18.1	0.779
Unit/kg/day
IGla-300	0.36±0.16	0.558	0.43±0.17	0.870	0.51±0.18	0.643
IDeg	0.38±0.20	0.558	0.42±0.21	0.870	0.49±0.21	0.643
Prandial insulin
Unit/day
IGla-300	18.7±12.4	0.552	25.1±19.9	0.055	24.5±14.6	0.185
IDeg	20.0±9.8	0.552	19.7±11.1	0.055	28.4±20.2	0.185
Unit/kg/day
IGla-300	0.26±0.17	0.404	0.35±0.27	0.070	0.37±0.21	0.451
IDeg	0.29±0.11	0.404	0.27±0.16	0.070	0.40±0.26	0.451
Total insulin
Unit/day
IGla-300	44.7±22.2	0.893	56.2±32.3	0.285	59.6±24.7	0.342
IDeg	45.3±24.1	0.893	51.0±25.1	0.285	64.3±33.2	0.342
Unit/kg/day
IGla-300	0.64±0.29	0.857	0.79±0.37	0.135	0.88±0.34	0.782
IDeg	0.64±0.24	0.857	0.69±0.28	0.135	0.89±0.38	0.782
B/T ratio
IGla-300	0.60±0.15	0.032	0.58±0.15	0.217	0.60±0.13	0.269
IDeg	0.55±0.11	0.032	0.61±0.14	0.217	0.57±0.15	0.269

B/T, basal/total insulin; HbA1c, glycosylated hemoglobin; IDeg, insulina degludec; IGla-300, insulina glargina 300 UI/mL; P, patients; T1D, type 1 diabetes.