Comparison of the risk of preterm birth among women treated with different types of antidepressants
| Population | Event | PMs | Rate (per 103 PMs) | Adjusted HR＊ | 95% CI | P value | |
| Total | 1789 | 87 | 16,373.60 | 5.31 | |||
| SSRIs | 408 | 21 | 4159.24 | 5.05 | Reference | ||
| TCAs | 380 | 20 | 4023.67 | 4.97 | 0.948 | 0.640 to 1.233 | 0.311 |
| SNRIs | 483 | 22 | 4762.79 | 4.62 | 0.816 | 0.523 to 1.197 | 0.489 |
| Others | 518 | 24 | 3427.91 | 7.00 | 1.199 | 0.986 to 1.581 | 0.062 |
*Adjusted for variables including age, income-related insurance premium, hospital types, urbanization levels, nulliparity or multiparity, multiple gestation, diabetes mellitus, hypertension, dyslipidemia, uteroplacental ischemia or hemorrhage, reproductive tract infection, pre-eclampsia, eclampsia, placenta previa, abruptio placenta, polycystic ovaries, hypogonadism, hypergonadism, pregnancy with history of infertility, morbid obesity or being overweight, and anxiety disorders.
CI, confidence interval; HR, hazard ratio; PMs, person-months; SNRI, serotonin norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.