Risk of chronic kidney disease progression according to follow-up SBP
| Follow-up SBP, mm Hg* | Unadjusted HR (95% CI) | Adjusted HR (95% CI)† | P value‡ |
| <110 | 1.3 (0.77 to 2.18) | 1.75 (1.03 to 2.97) | 0.038 |
| 110–119 | 1 | 1 | Reference |
| 120–129 | 1.85 (1.39 to 2.46) | 1.35 (1.01 to 1.81) | 0.043 |
| 130–139 | 2.04 (1.55 to 2.69) | 1.67 (1.23 to 2.26) | 0.001 |
| 140–149 | 2.94 (2.21 to 3.93) | 2.03 (1.45 to 2.86) | <0.001 |
| ≥150 | 7.01 (5.22 to 9.41) | 3.01 (2.01 to 4.5) | <0.001 |
*Defined as mean of all follow-up values beginning 6 months after randomization; if not available then last known BP was used.
†Adjusted for age, sex, race/ethnicity, body mass index, diabetes mellitus, cardiovascular disease, smoking status, baseline glomerular filtration rate, albuminuria/proteinuria category, baseline SBP, baseline DBP, time-updated SBP, time-updated DBP, and antihypertensive regimen (number of antihypertensive drug classes, ACE inhibitor/angiotensin receptor blocker, calcium channel blocker, or diuretic use at baseline and trial start).
‡For adjusted analysis.
BP, blood pressure; DBP, diastolic blood pressure; SBP, systolic blood pressure.