Multivariate logistic regression analysis for PAD associated with interaction cross-classified by eGFR and ACR
| Cross-classification of ACR and eGFR | Model I | Model II | ||
| OR 95% CI | P value | OR 95% CI | P value | |
| ACR <30 or eGFR ≥90 | (reference) | |||
| ACR 30–299 plus eGFR 60–89 | 1.76 (0.86 to 3.61) | 0.125 | 1.47 (0.71 to 3.07) | 0.300 |
| ACR 30–299 plus eGFR <30–59 | 2.66 (1.28 to 5.54) | 0.009 | 1.81 (0.84 to 3.87) | 0.129 |
| ACR 30–299 plus eGFR <30 | 3.73 (0.43 to 32.64) | 0.235 | 1.90 (0.21 to 17.19) | 0.568 |
| ACR >300 plus eGFR 60–89 | 2.45 (0.92 to 6.56) | 0.074 | 1.98 (0.73 to 5.38) | 0.181 |
| ACR >300 plus eGFR <30–59 | 5.73 (2.79 to 11.77) | <0.001 | 3.89 (1.84 to 8.23) | <0.001 |
| ACR >300 plus eGFR <30 | 9.97 (3.31 to 18.66) | <0.001 | 5.58 (2.58 to 12.06) | <0.001 |
| Age | 1.03 (1.01 to 1.05) | 0.019 | ||
| Hypertension | 2.15 (1.18 to 3.94) | 0.013 | ||
| Coronary artery disease | 2.58 (1.46 to 4.55) | 0.001 | ||
Model I: univariate analysis and model II: adjusted for age, hypertension, coronary artery disease, gender, DM duration, smoking, hyperlipidemia and HbA1c.
ABI, ankle-brachial index; ACR, albumin-to-creatinine ratio; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; PAD, peripheral arterial disease.