Clinical SLE disease activity and laboratory data in relation to autoantibody phenotype
| Nucleosome (+) (n=31) | Nucleosome (−) (n=247) | P value | dsDNA (+) (n=204) | dsDNA (−) (n=82) | P value | Sm (+) (n=35) | Sm (−) (n=256) | P value | RNP (+) (n=31) | RNP (−) (n=261) | P value | Ro (+) (n=108) | Ro (−) (n=184) | P value | La (+) (n=27) | La (−) (n=265) | P value | |
| Clinical activity | ||||||||||||||||||
| SLEDAI score | 3.87±2.72 | 2.52±2.76 | 0.004 | 3.08±2.91 | 2.04±2.48 | 0.010 | 3.14±2.76 | 2.73±2.84 | 0.449 | 3.63±3.05 | 2.69±2.80 | 0.149 | 2.60±2.73 | 2.87±2.89 | 0.453 | 2.89±2.57 | 2.76±2.86 | 0.852 |
| SDI score | 1.61±1.99 | 0.89±1.06 | 0.004 | 1.03±1.32 | 0.93±1.09 | 0.162 | 1.28±1.54 | 0.97±1.21 | 0.123 | 1.26±1.55 | 0.98±1.22 | 0.278 | 0.84±1.16 | 1.10±1.30 | 0.028 | 1.07±1.35 | 1.00±1.25 | 0.927 |
| Laboratory data | ||||||||||||||||||
| WBC (/µL) | 5577.22±1723.92 | 5689.36±2210.66 | 0.806 | 5814.12±2204.76 | 5507.53±2350.52 | 0.315 | 5663.05±2141.01 | 5708.07±2260.52 | 0.924 | 5383.79±1526.57 | 5738.30±2308.64 | 0.455 | 5372.88±2001.31 | 5907.97±2355.39 | 0.095 | 5321.92±2076.00 | 5748.21±2258.12 | 0.441 |
| Lymphocyte (/µL) | 1702.35±708.69 | 1628.45±764.86 | 0.777 | 1624.28±793.94 | 1634.46±667.69 | 0.868 | 1471.58±701.36 | 1651.70±764.15 | 0.197 | 1314.93±569.46 | 1666.15±769.33 | 0.023 | 1530.43±671.79 | 1689.25±800.91 | 0.087 | 1495.11±521.38 | 1644.24±778.26 | 0.335 |
| Hemoglobin (/µL) | 13.08±1.45 | 14.02±7.17 | 0.797 | 13.89±7.83 | 13.89±1.04 | 0.989 | 13.62±1.41 | 13.93±7.04 | 0.794 | 13.06±1.25 | 13.99±6.97 | 0.788 | 13.40±1.22 | 14.18±8.28 | 0.362 | 13.12±1.16 | 13.97±6.92 | 0.589 |
| Platelet (×1000 /µL) | 228.19±54.85 | 226.00±72.81 | 0.998 | 226.43±71.48 | 226.59±70.12 | 0.644 | 211.97±58.12 | 227.76±71.41 | 0.195 | 224.20±58.87 | 226.05±71.32 | 0.090 | 232.79±68.57 | 222.69±71.75 | 0.146 | 258.55±68.78 | 223.16±70.13 | 0.014 |
| ESR (mm/hour) | 25.60±18.86 | 18.33±14.61 | 0.039 | 20.74±16.94 | 15.53±10.71 | 0.015 | 21.37±18.75 | 18.85±14.96 | 0.340 | 27.06±18.40 | 18.22±14.84 | 0.008 | 21.57±16.26 | 17.84±14.90 | 0.042 | 23.34±17.33 | 18.83±15.28 | 0.177 |
| hs-CRP (mg/dL) | 4.11±3.72 | 3.20±5.08 | 0.078 | 3.61±5.50 | 2.37±2.82 | 0.030 | 3.21±4.92 | 3.25±4.90 | 0.938 | 4.12±5.59 | 3.14±4.81 | 0.556 | 3.44±6.14 | 3.11±3.99 | 0.415 | 5.34±10.40 | 3.03±3.93 | 0.017 |
| Hcy (µmol/L) | 11.65±3.36 | 12.65±7.76 | 0.584 | 11.74±4.69 | 14.18±11.18 | 0.023 | 11.80±4.09 | 12.54±7.58 | 0.642 | 12.57±4.34 | 12.44±7.52 | 0.886 | 12.41±5.62 | 12.46±8.08 | 0.955 | 13.69±9.49 | 12.32±7.91 | 0.348 |
| Albumin (g/dL) | 3.98±0.40 | 4.09±0.37 | 0.498 | 4.04±0.35 | 4.14±0.40 | 0.027 | 4.04±0.37 | 4.08±0.37 | 0.596 | 3.98±0.34 | 4.09±0.38 | 0.229 | 4.14±0.36 | 4.04±0.38 | 0.034 | 4.06±0.47 | 4.08±0.36 | 0.917 |
| AST (IU/L) | 21.94±8.35 | 23.57±11.09 | 0.820 | 24.03±10.87 | 22.65±10.65 | 0.407 | 23.46±8.30 | 23.74±11.05 | 0.838 | 27.69±9.86 | 23.29±10.84 | 0.088 | 22.38±6.34 | 24.60±12.92 | 0.237 | 23.41±9.31 | 23.74±10.96 | 0.920 |
| ALT (IU/L) | 20.52±8.20 | 19.28±9.43 | 0.535 | 19.20±8.90 | 20.33±10.39 | 0.440 | 20.52±10.46 | 19.60±9.38 | 0.468 | 24.66±10.74 | 19.20±9.23 | 0.018 | 19.20±6.65 | 19.95±10.67 | 0.933 | 21.29±7.53 | 19.54±9.64 | 0.356 |
| Complement C3 level (mg/dL) | 111.98±34.98 | 108.89±26.69 | 0.536 | 107.30±29.44 | 113.81±23.36 | 0.196 | 109.45±31.33 | 109.16±27.64 | 0.896 | 109.06±32.70 | 109.21±27.54 | 0.871 | 109.36±27.59 | 109.16±28.33 | 0.606 | 100.26±25–26 | 110.15±28.16 | 0.045 |
| Complement C4 level (mg/dL) | 22.88±15.93 | 22.91±17.16 | 0.996 | 22.63±18.86 | 22.88±9.28 | 0.970 | 20.42±9.98 | 23.11±17.42 | 0.407 | 22.77±9.79 | 22.79±17.35 | 0.982 | 24.08±20.99 | 22.05±13.53 | 0.371 | 21.64±10.12 | 22.92±17.23 | 0.726 |
Data are expressed as mean and range.
Bold values denote statistical significance (p<0.05).
ALT, alanine transaminase; AST, aspartate transaminase; dsDNA, double-stranded DNA; ESR, erythrocyte sedimentation rate; Hcy, homocysteine; hs-CRP, high-sensitivity C reactive protein; RNP, ribonucleoprotein; SDI, Damage Index for Systemic Lupus Erythematosus; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; Sm, Smith; WBC, white blood cell.