Global and sex-specific associations between gout and risk of AMI
| Gout cohort | Non-gout cohort | Crude HR (95% CI) | Adjusted HR (95% CI) | P value for interaction | |||||
| AMI cases (n) | PYs | Incidence rate (per 10,000) | AMI cases (n) | PYs | Incidence rate (per 10,000) | ||||
| Total | 80 | 41,100 | 19.46 | 182 | 124,020 | 14.68 | 1.33 (1.02 to 2.73) | 1.36 (1.04 to 2.76) | |
| Sex | 0.020 | ||||||||
| Female | 7 | 7920 | 8.84 | 38 | 23,932 | 15.88 | 0.56 (0.25 to 1.26) | 0.55 (0.25 to 1.24) | |
| Male | 73 | 33,179 | 22.00 | 144 | 100,088 | 14.39 | 1.53 (1.16 to 2.03) | 1.57 (1.18 to 2.08) | |
HRs were adjusted for age, sex, the index year, comorbidities, including hypertension, diabetes mellitus, hyperlipidemia, cerebrovascular disease, chronic obstructive pulmonary disease, chronic kidney disease, alcoholic liver disease, and malignant neoplasms, as well as frequency of annual outpatient visits for the global association and were adjusted for age, the index year, aforementioned comorbidities, and frequency of annual outpatient visits for sex-specific associations between gout and risk of AMI.
P value for interaction refers to the interactive effect of sex and gout on the risk of AMI.
AMI, acute myocardial infarction; PYs, person-years.