Table 1

Summary of COVID-19 reinfection cases with confirmed genomic differences

Patient	Date reported	Age/sex	Immuno compromised	Interval (days)	Symptom severity* (first episode)	Symptom severity (second episode)	Negative PCR test in between infections	Seroconversion after initial infection	Seroconversion after second infection	Viral clade (first episode)	Viral clade (second episode)	Recovered	Country	References†
1	May 20	42/M	No	51	Mild	Mild	Not performed	Not performed	Not performed	B.1.26	B.1.26 but with several mutations	Yes	USA	Larson et al, 2020
2	June 20	25/M	No	48	Mild	Moderate‡	Yes	Not performed	Yes	20C	20C with 11 SNP mutations	Yes	USA	Tillett et al, 2020
3	June 20	51/F	No	120	Mild	Mild	Not performed	Not performed	Not performed	B.1.1	A	Yes	Belgium	Van Elslande et al, 2020
4	July 20	60/M	No	140	Moderate	Mild	Yes	Not performed	Yes	19B	20A	Yes	USA	Goldman et al, 2020
5	July 20	33/M	No	142	Mild	Asymptomatic	Yes	Yes	Yes	D614 (V/19A;B.2)	G614 (G20A, B.1)	Yes	China	To et al 12
6	July 20	46/M	No	68	Mild	Mild	Yes	Not performed	Yes	B1.p9	A.1.1	Yes	Ecuador	Prado et al, 2020
7	July 20	89/F	Yes	59	Mild	Severe‡	Not performed	Not performed	No	N/A	10 SNP mutations	No	The Netherlands	Mulder et al 4
8	July 20	27/M	No	66	Mild	Mild	Yes	Not performed	No	B.1	B, 8 SNP mutations	Yes	India	Shastri et al, 2020
9	July 20	31/M	No	65	Asymptomatic	Mild‡	Yes	Not performed	No	B.1.1	B.1.1, 9 SNP mutations	Yes	India	Shastri et al, 2020
10	July 20	27/M	No	19	Asymptomatic	Mild‡	Yes	Not performed	Not performed	B.1.1	B.1.1, 9 SNP mutation	Yes	India	Shastri et al, 2020
11	July 20	24/F	No	55	Mild	Mild	Not performed	Not performed	No	B.1.1	B.1.1, 12 SNP mutations	Yes	India	Shastri et al, 2020
12	August 20	47/F§	N/A	88	Mild	Mild	Not performed	Not performed	No	D614	G614	Yes	Qatar	Abu-Raddad et al, 2020
13	August 20	27/M§	N/A	46	Mild	Mild	Not performed	Not performed	Not performed	D614	G614	Yes	Qatar	Abu-Raddad et al, 2020
14	August 20	42/M§	N/A	71	Mild	Mild	Not performed	Not performed	Not performed	D614	G614	Yes	Qatar	Abu-Raddad et al, 2020
15	August 20	27/M§	N/A	55	Mild	Mild	Not performed	Not performed	Not performed	D614	G614	Yes	Qatar	Abu-Raddad et al, 2020
16	August 20	25/M	No	106	Asymptomatic	Asymptomatic	Yes	Not performed	Not performed	N/A	9 SNP mutations	Yes	India	Gupta et al, 2020
17	September 20	28/F	No	107	Asymptomatic	Asymptomatic	Yes	Not performed	Not performed	N/A	10 SNP mutations	Yes	India	Gupta et al, 2020

*Symptom severity was classified as follows: severe: intensive care unit admission; moderate: supplemental oxygen with nasal cannula; mild; no oxygen support but other COVID-19 symptoms (which may include cough, rhinorrhea, sore throat, shortness of breath, change in taste or smell, headache, nausea, vomiting, diarrhea, fever, chills, fatigue, and myalgias).
†See full citations in the online supplemental file.
‡Worse symptoms at second infection compared with the first infection.
§Only age range was reported in this study, so an average number is taken, that is, 47 for range 45–49 years.
F, female; M, male; N/A, not applicable; SNP, single-nucleotide polymorphism.