P value | Univariate analysis | P value | Multivariate analysis | |
OR (95% CI) | OR (95% CI) | |||
Age (years) | 0.389 | – | – | – |
Gender (male vs female) | 0.687 | – | – | – |
Total bilirubin (mg/dL) | 0.001* | 1.688 (1.243 to 2.293) | 0.242 | – |
ALT (U/L) | <0.001* | 1.036 (1.022 to 1.051) | 0.923 | – |
AST (U/L) | <0.001* | 1.030 (1.018 to 1.041) | 0.270 | – |
ALK (U/L) | 0.044* | 1.012 (1.000 to 1.023) | 0.121 | – |
Albumin (g/dL) | <0.001* | 0.434 (0.278 to 0.679) | 0.152 | – |
INR | 0.029* | 1.067 (1.055 to 2.641) | 0.137 | – |
AFP (ng/mL) | <0.001* | 1.012 (1.007 to 1.016) | 0.001* | 1.016 (1.006 to 1.026) |
NRP-1 (pg/mL) | <0.001* | 1.002 (1.001 to 1.003) | 0.002* | 1.002 (1.001 to 1.003) |
ANG-2 (pg/mL) | <0.001* | 1.001 (1.001 to 1.002) | 0.122 | – |
*P<0.05 significant.
AFP, alpha-fetoprotein; ALK, alkaline phosphatase; ALT, alanine transaminase; ANG-2, angiopoietin-2; AST, aspartate transaminase; HCC, hepatocellular carcinoma; INR, international normalized ratio; NRP-1, neuropilin-1.