Table 4

Agreement (sensitivity, specificity) with netrin-1 to predict incipient DN

	AUC	P value	95% CI		Cut-off	Sensitivity	Specificity
	AUC	P value	LL	UL	Cut-off	Sensitivity	Specificity
Incipient DN (microalbuminuria) versus T2DM (normoalbuminuria)
Serum netrin-1 (pg/mL)	0.812	<0.001*	0.715	0.886	>162	60	84.4
Urinary netrin-1 (pg/mg creatinine)	0.916	<0.001*	0.839	0.964	>720	77.8	84.4
Combined netrin-1	0.938	<0.001*	0.867	0.978	–	–	–
Overt DN (macroalbuminuria) versus incipient DN (microalbuminuria)
Serum netrin-1 (pg/mL)	0.939	<0.001*	0.868	0.978	>250	86.7	93.3
Urinary netrin-1 (pg/mg creatinine)	0.931	<0.001*	0.857	0.973	>1450	80	95.6
Combined netrin-1	0.958	<0.001*	0.893	0.989	–	–	–

Cut-off was chosen according to Youden’s index.
*Significant at p<0.05.
AUC, area under the curve; ;DN, diabetic nephropathy; LL, lower limit; T2DM, type 2 diabetes mellitus; UL, upper limit.