Table 2

Effects of HbO2 treatment on ROS and RNS

Plasma ROS/RNSMedian difference
Immediately before to after HBO2 After HBO2 to follow-up sample
AllSeptic shockNon-shock sepsisAllSeptic shockNon-shock sepsis
MPO (ng/mL)3.4* 4.63.4* −11.0* −14.2* 1.6
SOD (ng/mL)8.8* −1.914.4−19.1** −24.4* −10.1*
HO-1 (pg/mL)17.9301.3* −172.3−11.6−513.565.6
Nitrite+nitrate (µM)−0.190.01−0.20
  • Data are compared immediately before and after the first HbO2 treatment session (left), as well as after the first HbO2 treatment session and following day (right). Differences are presented as median differences across the overall cohort (n=80), patients admitted in septic shock (n=39) and patients without septic shock (n=41). Superscripts indicate level of statistical significance performed by Wilcoxon signed-rank test. A positive value indicates significant upregulation (); a negative value indicates significant downregulation ().

  • **P<0.05, **P<0.01.

  • HBO2, hyperbaric oxygen; HO-1, heme oxygenase-1; MPO, myeloperoxidase; RNS, reactive nitrogen species; ROS, reactive oxygen species; SOD, superoxide dismutase.