Table 5

Accuracy of high baseline biomarker (defined by being above the optimal cut-off point) level in predicting 90-day mortality

MPOSODHO-1Nitrite+nitrate
Sensitivity0.25
(0.05–0.57)		0.92
(0.62–1.00)		0.80
(0.44–0.97)		0.17
(0.02–0.48)
Specificity0.85
(0.74–0.92)		0.52
(0.40–0.65)		0.55
(0.42–0.68)		0.88
(0.78–0.95)
PPV0.23
(0.05–0.54)		0.26
(0.14–0.42)		0.22
(0.10–0.39)		0.20
(0.03–0.56)
NPV0.85
(0.74–0.92)		0.97
(0.85–1.00)		0.94
(0.81–0.99)		0.86
(0.75–0.93)
AUC-ROC0.48
(0.31–0.66)		0.69
(0.51–0.87)		0.69
(0.49–0.88)		0.61
(0.43–0.79)

  • Data are presented as fractions (95% CI).

  • AUC-ROC, area under the receiver operating characteristic curve; HO-1, heme oxygenase-1; MPO, myeloperoxidase; NPV, negative predictive value; PPV, positive predictive value; SOD, superoxide dismutase.