Studies on the efficacy of intravaginal probiotics in preventing recurrent UTIs
| First author’s last name, Year of Publication, Location of study | Name of Probiotic | Duration and frequency of usage (intravaginal) | Number of Subjects and controls | Frequency of UTIs in subjects vs controls | P value |
|---|---|---|---|---|---|
| Reid, 1992, Canada | L casei rhamnosus and L fermentum | Twice a week for 2 weeks then once monthly | 19 vs 21 | 21% vs47% | p<0.05 |
| Baerheim, 1994, Norway | L casei rhamnosus | Twice a week for 26 weeks | 25 vs 22 | Incidence ratio=1.4 | 95% CI=0.88 to 1.98 (p>0.05) |
| Reid, 1995, Canada | L. rhamnosus and L-fermentum | Once a week 1 year | 55 subjects, baseline was control | Episodes decreased from 6 to 1.6/yr | p<0.001 |
| Uehara, 2006, Tokyo | L. Cirspatus (Lactin-V) | Every 2 days for 1 year | 9 Subjects, baseline was control | Recurrences decreased from 5.0/yr to 1.3/yr | p=0.0007 |
| Stapleton, 2011, USA | L. Cirspatus (Lactin-V) | 5 days, then weekly for 10 weeks | 50 vs 50 | 15% vs 27% | p<0.01 |