Approved MS DMTs and pregnancy ratings
| DMT | Type of DMT | Pregnancy ratings | Use in pregnancy |
| Interferon-beta | Injectable DMT | Category C | Should not be used since adverse effects were reported in animal reproduction studies. |
| Glatiramer acetate | Injectable DMT | Category B | Can be used safely and routinely. |
| Peginterferon-beta 1a | Injectable DMT | Category C | Should not be used since adverse effects were reported in animal reproduction studies. |
| Fingolimod | Oral DMT | Category C | Should not be used since adverse effects were reported in animal reproduction studies. |
| Dimethyl fumarate | Oral DMT | Category C | Should not be used since adverse effects were reported in animal reproduction studies. |
| Teriflunomide | Oral DMT | Category X | These drugs have serious adverse effects that outweigh the potential benefits. |
| Alemtuzumab | Infusion DMT | Category C | Should not be used since adverse effects were reported in animal reproduction studies. |
| Natalizumab | Infusion DMT | Category C | Should not be used since adverse effects were reported in animal reproduction studies. |
| Mitoxantrone | Infusion DMT | Category D | Not advised since it has adverse effects on the fetus. |
Category B drugs: these drugs can be used safely and routinely during pregnancy.
Category C drugs: their adverse effects on the fetus have been shown in animal reproduction studies.
Category D drugs: these drugs were analyzed using data from investigational and human studies.
Category X drugs: their adverse effects have been proven through animal and human research models.
DMT, disease-modifying therapy; MS, multiple sclerosis.