Cardiac characteristics and long-term outcomes in patients with multisystem inflammatory syndrome in children (MIS-C)
| Author, Location, Year | Mean/Median Age (years) | Initial LV Dysfunction/Decreased LVEF (%) | Initial Dilations (%) | Initial Aneurysms (%) | Elevated Troponin (%) | Myocarditis, MR, PCE (%) | Follow-up LV Dysfunction/Decreased LVEF (%) | Follow-up Dilations (%) | Follow-up Aneurysms (%) | Follow-up Period |
|---|---|---|---|---|---|---|---|---|---|---|
| Minocha et al., NYC, 2021 | 2.8 | 4/33 (13%) | 2/33 (7%) | 0/33 (0%) | 7/32 (22%) | 1/33 (5%), 5/33 (15%), 1/33 (3%) | 0/33 (0%) | 0/33 (0%) | 0/33 (0%) | 14 days |
| Gaitonde et al., Georgia, 2020 | 8 | 8/12 (67%) | 1/12 (8%) | 0/12 (0%) | - | MR: 12/12 (100%), PCE: 5/12 (42%) | 1/12 (8%) | 2/12 (17%) | 0/12 (0%) | Median = 45 days |
| Clouser et al., USA, 2021 | 7.3 | 7/18 (39%) | 0/18 (0%) | 0/18 (0%) | - | PCE: 2/18 (11%) | 1/11 (9%) | 1/11 (9%) | 0/11 (0%) | Median = 29 days |
| Dionne et al., USA, 2020 | 9.7 | 15/25 (60%) | 3/25 (12%) | 2/25 (8%) | 2/25 (8%) | - | 2/15 (13%) | - | - | Median = 51 days |
| Penner et al., UK, 2021 | 10.2 | 15/46 (33%) | 38/45 (84%) | PCE: 1/46 (2%) | 0/46 (0%) | 1/46 (2%) | 1/46 (2%) | 6 months | ||
| Kelly et al., Boston, 2020 | 3.5 | 7/12 (58%) | 1/12 (8%) | 1/12 (8%) | 9/12 (75%) | MR: 3/12 (25%), PCE: 4/12 (33%) | 1/8 (13%) | 2/8 (25%) | 1/8 (13%) | Median = 16.5 days |
| Jhaveri et al., NYC, 2021 | 11.5 | 8/15 (53%) | - | 4/15 (33%) | - | MR: 8/15 (53%), PCE: 2/15 (13%) | 3/13 (23%) | - | 1/13 (8%) | Median = 28.1 days |
| Feldstein et al., US, 2021 | 9.7 | 172/539 (34%) | - | 57/424 (13%) | - | PCE: 125/539 (25%) | 1/172 (0.58%) | - | 12/172 (7%) | 2–20 weeks |
| Kobayashi et al., Canada, 2021 | 11.4 | 9/25 (36%) | 2/25 (8%) | 4/26 (16%) | 9/23 (39%) | MR: 1/25 (4%), PCE: 0/25 (0%) | 2/9 (22%) | - | - | 1–2 months |
| Totals | 2.8–11.5 | 13–60% | 0–12% | 0–33% | 8–84% | - | 0–23% | 0–25% | 0–13% | 2 weeks- 6 months |