Table 4

Simple and final adjusted HR from CPH of risk factors for graft failure in 552 patients with Nocardia infection

Risk factor		Simple models			Final adjusted model
Risk factor	Level	HR	95% CI	P value	aHR	95% CI	P value
Demographic variables
Sex	Female vs male	0.98	0.64 to 1.51	0.9287	–		–
Race	Black vs white	0.61	0.35 to 1.07	0.0835	–		–
Race	Other vs white	0.68	0.25 to 1.88	0.4612	–		–
Ethnicity	Hispanic vs non-Hispanic	0.82	0.43 to 1.59	0.5581	–		–
Age at transplant	65+ vs <65	0.78	0.43 to 1.4	0.3986	0.63	0.34 to 1.15	0.1309
Transplant-related variables
History of transplant failure	Yes vs no	0.43	0.2 to 0.93	0.0317	0.41	0.18 to 0.91	0.0280
History of rejection	Yes vs no	0.56	0.36 to 0.85	0.0067	0.52	0.33 to 0.80	0.0032
Donor type	Cadaver vs living	0.98	0.61 to 1.58	0.9444	–		–
Antithymocyte	Yes vs no	1.68	0.73 to 3.85	0.2212	2.76	1.16 to 6.55	0.0213
Azathioprine	Yes vs no	0.79	0.47 to 1.35	0.3903
Basiliximab	Yes vs no	1.43	0.85 to 2.4	0.1789	1.51	0.89 to 2.59	0.1299
Cyclosporine	Yes vs no	0.78	0.47 to 1.32	0.3552	–		–
Muromonab	Yes vs no	0.75	0.36 to 1.54	0.4282	–		–
Mycophenolate	Yes vs no	0.85	0.51 to 1.41	0.5294	–		–
Prednisone	Yes vs no	3.08	0.43 to 22.14	0.2630	–		–
Sirolimus	Yes vs no	0.56	0.27 to 1.17	0.1229	0.54	0.26 to 1.14	0.1046
Steroid	Yes vs no	0.79	0.25 to 2.49	0.6846	–		–
Tacrolimus	Yes vs no	1.15	0.67 to 1.95	0.6132	–		–
Thymoglobulin	Yes vs no	0.74	0.47 to 1.17	0.1972	–		–
Clinical diagnoses
Cytomegalovirus	Dx vs no Dx	1.42	0.77 to 2.62	0.2550	1.73	0.92 to 3.23	0.0937
COPD	Dx vs no Dx	2.05	1.18 to 3.58	0.0113	2.47	1.40 to 4.35	0.0018
Diabetes	Dx vs no Dx	1.16	0.76 to 1.76	0.4979	–		–
Hepatitis C	Dx vs no Dx	1.50	0.61 to 3.71	0.3752	–		–
Asthma	Dx vs no Dx	0.61	0.22 to 1.67	0.3387	0.50	0.18 to 1.38	0.1815
Tobacco	Dx vs no Dx	1.27	0.77 to 2.12	0.3508	–		–
Clinical presentation of Nocardia infection
Pneumonia	Dx vs no Dx	1.29	0.75 to 2.22	0.3548	–		–
Brain abscess	Dx vs no Dx	2.03	1.12 to 3.65	0.0189	1.85	1.02 to 3.36	0.0437
Bacteremia	Dx vs no Dx	1.87	0.59 to 5.92	0.2867	–		–

Antithymocyte globulin refers to horse origin globulin (Atgam) and thymoglobulin is rabbit antithymocyte globulin.
aHR, adjusted hazard ratio; COPD, chronic obstructive pulmonary disease; CPH, Cox proportional hazards; Dx, diagnosis; USRDS, US Renal Data System.