Abstract #87 Table 1

Patient characteristics during feeding protocol changes

Epoch 1: Baseline
(September 2015 – April 2016)
N=51 (12%)
Epoch 2: Introduction of Donor Breast Milk (DBM)
(May 2016 – June 2018)
N=102 (24%)
Epoch 3: Stopped routine gastric aspirates
(July 2018 – October 2020)
N=108 (26%)
Epoch 4: Introduction of Human-milk-based fortifier
(November 2018 – December 2020)
N=161 (38%)
p-value
Female Sex 29 (57%) 51 (50%) 49 (45%) 88 (55%) 0.8344
Birth GA (weeks), mean (SD) 27.5 (2.8) 28.1 (2.6) 27.5 (2.7) 28 (2.6) 0.3346
Birth Weight (grams), mean (SD) 913 (214) 919 (200) 896 (225) 942 (192) 0.3478
Race: Non-Hispanic White
Race: Non-Hispanic Black
18 (37%)
28 (57%)
35 (34%)
55 (54%)
34 (31%)
60 (56%)
37 (23%)
104 (65%)
0.2573
No antenatal steroids 5 (10%) 5 (5%) 7 (6%) 11 (7%) 0.5110
SGA (<10%tile) 11 (22%) 39 (39%) 35 (32%) 55 (34%) 0.1795
DOL first feed, median (IQR) 3.5 (2-7) 3 (2-5) 3 (2-5) 2 (1-3) <0.0001
DOL first Maternal Breast Milk (MBM), median (IQR) 4 (3-9) 3 (2-4) 3 (2-5) 2 (1-3) <0.0001
DOL full feeds (150ml/kg/day), median (IQR) 21 (17-36) 21 (15-36) 19 (15-40) 16 (11-30) 0.0003
DOL started first formula, median (IQR) 23 (10-48) 38 (25-59) 47 (33-62) 38 (23-51) 0.0007
Ever received MBM 43 (84%) 92 (91%) 93 (87%) 142 (88%) 0.6365
Received Donor Breast Milk (DBM) 0 (0%) 39 (39%) 52 (50%) 90 (57%) <0.0001
Received Human-milk-based human-milk fortifier (HMBHMF) 0 (0%) 0 (0%) 0 (0%) 113 (71%) <0.0001
Ever received formula 36 (72%) 73 (72%) 78 (73%) 89 (56%) 0.0089
NEC (any Bell stage 1-3) 7 (14%) 18 (18%) 15 (14%) 17 (11%) 0.4498
NEC Stage 2 or 3 2 (3.9%) 11 (11%) 9 (8%) 6 (3.7%) 0.1049
UVC placed 40 (78%) 86 (84%) 88 (81%) 129 (80%) 0.7932
PICC or surgical CVL placed 46 (94%) 92 (90%) 94 (88%) 126 (78%) 0.0080
DOL all central lines removed, median (IQR) 21 (17-43) 22.5 (15-44.5) 19 (14.5-41.5) 15 (11-26) <0.0001
DOL last parenteral nutrition, median (IQR) 23 (17-41) 23 (16-52) 26 (15-58.5) 18 (11-34) 0.0008
IVH Grade III/IV 3 (6%) 6 (6%) 15 (14%) 12 (7%) 0.5275
Periventricular leukomalacia (PVL) 2 (4%) 7 (7%) 18 (17%) 10 (6%) 0.0104
ROP requiring treatment 3 (8%) 4 (5%) 6 (6%) 4 (3%) 0.6969
Late onset sepsis (blood culture positive) 2 (4%) 8 (8%) 11 (10%) 23 (14%) 0.1269
FiO2 >21% at 36 weeks PMA 31 (61%) 58 (57%) 62 (57%) 69 (44%) 0.0427
Spontaneous intestinal perforation (SIP) 1 (2%) 6 (6%) 5 (5%) 6 (4%) 0.6933
Death prior to discharge 4 (8%) 4 (4%) 3 (3%) 10 (6%) 0.4229
Daily weight gain, birth to 4 weeks of life (g/kg/day), median (IQR) 14 (11-19) 15 (10-21) 15 (10-20) 13 (9-18) 0.1043
Daily weight gain, birth to 6 weeks of life (g/kg/day), median (IQR) 19 (14-22) 19 (13-23) 19 (14-23) 17 (13-21) 0.1847
  • DOL, day of life; HMBHMF, human-milk-based human-milk fortifier; MBM, maternal breast milk; PN, parenteral nutrition