SNP#1 | Gene | SNP#2 | Gene | SNP#3 | Gene | Interaction type | p value | LR | OR |
---|---|---|---|---|---|---|---|---|---|
rs1059046 rs1130866 | SFTPA2 SFTPB | rs1136451 rs4715 | SFTPA2 SFTPC | dd dd | <0.001 <0.001 | 18.6 18.6 | 2.2 2.2 | ||
rs1059046 | SFTPA2 | rs17886395 | SFTPA2 | rs1136450 | SFTPA1 | ddd | <0.001 | 18.8 | 2.2 |
rs1059046* | SFTPA2 | rs1965707 | SFTPA2 | rs721917 | SFTPD | add | <0.001 | 21.9 | 0.2 |
rs1059046* | SFTPA2 | rs1059047 | SFTPA1 | rs4253527 | SFTPA1 | ddd | <0.001 | 27 | 0.4 |
rs1059046 | SFTPA2 | rs1136450 | SFTPA1 | rs1136451 | SFTPA1 | ddd | <0.001 | 21.8 | 1.6 |
rs1059046 | SFTPA2 | rs1136450 | SFTPA1 | rs4253527 | SFTPA1 | ddd | <0.001 | 23.6 | 1.8 |
rs1059046* | SFTPA2 | rs1059057 | SFTPA1 | rs4252527 | SFTPA1 | ddd | <0.001 | 20 | 0.5 |
rs17886395* | SFTPA2 | rs1965708 | SFTPA2 | rs1124 | SFTPC | ddd | <0.001 | 20.8 | 0.4 |
rs17886395 | SFTPA2 | rs4253527 | SFTPA1 | rs1130866 | SFTPB | ddd | <0.001 | 25.1 | 2.3 |
rs1965707 | SFTPA2 | rs1965708 | SFTPA2 | rs2077079 | SFTPB | daa | <0.001 | 17.1 | 2.6 |
rs1965707 | SFTPA2 | rs1136450 | SFTPA1 | rs721917 | SFTPD | dad | <0.001 | 17.9 | 4.9 |
rs1965708* | SFTPA2 | rs1059047 | SFTPA1 | rs1059057 | SFTPA1 | ddd | <0.001 | 15.9 | 3.4 |
rs1965708* | SFTPA2 | rs1136450 | SFTPA1 | rs721917 | SFTPD | ddd | <0.001 | 18.2 | 0.6 |
rs1965708 | SFTPA2 | rs1130866 | SFTPB | rs2077079 | SFTPB | ddd | <0.001 | 21.1 | 3.6 |
rs1965708 | SFTPA2 | rs1130866 | SFTPB | rs3024798 | SFTPB | ddd | <0.001 | 15.9 | 3.4 |
rs1965708* | SFTPA2 | rs721917 | SFTPD | rs3024798 | SFTPB | ddd | <0.001 | 19.7 | 0.4 |
rs1059047** | SFTPA1 | rs1136451 | SFTPA1 | rs1059057 | SFTPA1 | dad | <0.001 | 18.3 | 0.2 |
rs1136450 | SFTPA1 | rs1136451 | SFTPA1 | rs721917 | SFTPD | add | <0.001 | 18.8 | 2.8 |
rs1136451 | SFTPA1 | rs1059057 | SFTPA1 | rs2077079 | SFTPB | dda | <0.001 | 17.5 | 2.7 |
rs1136451* | SFTPA1 | rs1059057 | SFTPA1 | rs3024798 | SFTPB | aad | <0.001 | 18.5 | 0.2 |
rs1136451 | SFTPA1 | rs1059057 | SFTPA1 | rs2077079 | SFTPB | dda | <0.001 | 17.5 | 2.7 |
rs1136451 | SFTPA1 | rs4253527 | SFTPA1 | rs1124 | SFTPC | add | <0.001 | 15.9 | 2.4 |
rs1136451 | SFTPA1 | rs4253527 | SFTPA1 | rs3024798 | SFTPB | add dad | <0.001 <0.001 | 17.7 18 | 5.7 3.2 |
rs1136451 | SFTPA1 | rs4715 | SFTPC | rs721917 | SFTPD | daa | <0.001 | 17.2 | 9.4 |
rs1059057 | SFTPA1 | rs4253527 | SFTPA1 | rs1130866 | SFTPB | ddd | <0.001 | 16.0 | 2.4 |
rs1059057 | SFTPA1 | rs4253527 | SFTPA1 | rs3024798 | SFTPB | add | <0.001 | 15.9 | 3.8 |
rs1059057 | SFTPA1 | rs1130866 | SFTPB | rs4715 | SFTPC | add | <0.001 | 17.5 | 2.0 |
rs4253527* | SFTPA1 | rs1130866 | SFTPB | rs4715 | SFTPC | add dda | <0.001 <0.001 | 15.4 20.7 | 2.1 0.2 |
rs4253527* | SFTPA1 | rs1130866 | SFTPB | rs4715 | SFTPC | dda | <0.001 | 21.9 | 0.2 |
SNP-single nucleotide polymorphism, LR-Likelihood ratio, OR-Odds ratio, dd- dominant x dominant, ddd-dominant x dominant x dominant, add-additive x dominant x dominant, daa-dominant x additive x additive, dad-dominant x additive x dominant, dda- dominant x dominant x additive, aad- additive x additive x dominant. ‘**’ shows intragenic interaction AND decreased risk of severe RSV (OR <1). ‘*’ shows interactions that are associated with decreased risk of severe RSV (OR < 1).