Comparing cohorts pre- and post-RGA cessation
| Routine Gastric Aspirates Cohort (September 2015 – June 2018) n=230 | No Routine Gastric Aspirates Cohort (July 2018 – December 2020) n=192 | p-value | |
|---|---|---|---|
| Female Sex | 117 (51%) | 110 (57%) | 0.1876 |
| Birth Gestational Age, weeks [mean (SD)] | 27.7 (2.6) | 27.9 (2.6) | 0.4369 |
| Birth Weight, grams [mean (SD)] | 913 (886) | 932 (903) | 0.3523 |
| Race: Non-Hispanic Black Non-Hispanic White | 79 (35%) 123 (54%) | 45 (23%) 124 (65%) | 0.1002 |
| No antenatal steroids | 13 (6%) | 15 (8%) | 0.6600 |
| Small for Gestational Age (SGA) <10%tile at birth | 74 (33%) | 65 (34%) | 0.8602 |
| Maternal Chorioamnionitis | 27 (12%) | 15 (8%) | 0.1315 |
| Day of life (DOL) first feed [median (IQR)] | 3 (2-5) | 2 (1-3) | <0.0001 |
| Day of life (DOL) full feeds 150ml/kg/day [median (IQR)] | 20 (15-37) | 16 (11-31) | 0.0002 |
| Day of life (DOL) first mother’s breast milk (MBM) [median (IQR)] | 3 (2-5) | 2 (1-3) | <0.0001 |
| Day of life (DOL) started formula feeds [median (IQR)] | 38 (24-58) | 41 (26-55) | 0.9460 |
| Ever received MBM | 200 (87%) | 170 (89%) | 0.5989 |
| Received Donor Breast Milk (DBM) | 84 (37%) | 105 (56%) | <0.0001 |
| Received human-milk-based fortifier | 3 (1%) | 118 (62%) | <0.0001 |
| Ever received formula feeds | 165 (72%) | 111 (59%) | 0.0042 |
| Umbilical venous catheter placed | 188 (82%) | 155 (81%) | 0.7911 |
| Umbilical arterial catheter placed | 139 (60%) | 108 (57%) | 0.4197 |
| PICC or surgical central line placed | 206 (90%) | 152 (80%) | 0.0019 |
| Day of life (DOL) all central lines removed [median (IQR)] | 20.5 (16-43) | 16 (11-27) | <0.0001 |
| Day of life (DOL) last parenteral nutrition (PN) [median (IQR)] | 23.5 (16-50) | 19 (12-38) | 0.0005 |
| NEC (any Bell Stage 1-3) | 36 (16%) | 21 (11%) | 0.1644 |
| NEC (Bell Stage 2 or 3) | 19 (8.3%) | 9 (5%) | 0.1419 |
| Day of life (DOL) stage 2 or 3 NEC diagnosis [mean (SD)] | 38 (25) | 31 (14) | 0.1811 |
| Post-menstrual age (PMA) stage 2 or 3 NEC diagnosis [mean (SD)] | 31.9 (3.6) | 31.2 (2.4) | 0.4117 |
| Spontaneous intestinal perforation (SIP) | 10 (4%) | 8 (4%) | 0.9359 |
| Periventricular leukomalacia (PVL) | 24 (11%) | 13 (7%) | 0.1821 |
| Retinopathy of prematurity (ROP) requiring treatment | 10 (5%) | 7 (4%) | 0.5008 |
| Death before discharge | 10 (4%) | 11 (6%) | 0.7020 |
| Feeds at Discharge: Breast milk Formula Both | 66 (29%) 113 (51%) 44 (20%) | 76 (42%) 82 (45%) 24 (13%) | 0.0242 |