NAFLD and comorbidities in children with DS
| Variables | G1 (n=17) | G2 (n=21) | p value |
|---|---|---|---|
| Age (years) mean (SD) | 7.9 (5.3) | 11.4 (4.8) | 0.02 |
| Gender (female) (%) | 6 (35) | 9 (43) | 0.64 |
| Ethnicity | 0.85 | ||
| Hispanic (%) | 9 (53) | 10 (48) | |
| African-American (%) | 7 (41) | 9 (43) | |
| Asian (%) | 1 (6) | 1 (5) | |
| Caucasian (%) | 0 | 0 | |
| Other (%) | 0 | 1 (5) | |
| Elevated AST (%) | 3 (18) | 6 (29) | 0.43 |
| Elevated ALT (%) | 1 (5.8) | 1 (4.8) | 0.95 |
| Liver imaging (%) | 0 | 0 | |
| Liver biopsy (%) | 0 | 0 | |
| Comorbidities | |||
| Dyslipidemia (%) | 2/7 (29) | 5/15 (33) | 0.82 |
| Insulin resistance (%) | 0 | 3/8 (38) | N/A |
| Hemoglobin A1c >5.7% (%) | 0 | 2/8 (25) | N/A |
| 25OH vitamin D <32 ng/ml (%) | 5 (29) | 8 (38) | 0.79 |
| Hypertension (%) | 0 | 0 | |
| Hypothyroidism (%) | 5/13 (39) | 9/20 (45) | 0.71 |
| Congenital heart disease (%) | 9 (53) | 10 (48) | 0.74 |
| Apnea (%) | 0 | 1 (5) | 0.36 |
| Nutrition consultation (%) | 0 | 1 (5) | 0.36 |
p<0.05 was considered significant