Multivariate analysis of patients with early stage GC
| Variables | HR (95% CI) | P value |
| Statistically significant factors | ||
| Age at diagnosis (years) | <0.001 | |
| ≤40 vs 41–50 | 0.048 (0.019–0.122) | <0.001 |
| ≤40 vs 51–60 | 0.086 (0.050–0.147) | <0.001 |
| ≤40 vs 61–70 | 0.110 (0.073–0.166) | <0.001 |
| ≤40 vs 71–80 | 0.133 (0.091–0.195) | <0.001 |
| ≤40 vs 81–90 | 0.213 (0.148–0.305) | <0.001 |
| ≤40 vs 91–100 | 0.462 (0.322–0.663) | 0.303 |
| Gender (male vs female) | 0.690 (0.579–0.823) | <0.001 |
| Histology | 0.001 | |
| Adenocarcinoma versus signet ring cell carcinoma | 3.039 (2.054–4.496) | 0.001 |
| Adenocarcinoma versus special type | 2.122 (1.365–3.297) | 0.001 |
| Adenocarcinoma versus unknown | 0.866 (0.515–1.457) | 0.763 |
| Adenocarcinoma versus other | 2.893 (1.733–4.829) | 0.068 |
| Stage_T | <0.001 | |
| T1a versus T1b | 0.731 (0.592–0.903) | <0.001 |
| T1a versus T1NOS | 0.829 (0.673–1.020) | 0.045 |
| Stage_N | 0.052 | |
| N0 vs N1 | 0.550 (0.351–0.861) | 0.483 |
| N0 vs N2 | 0.962 (0.576–1.608) | 0.419 |
| N0 vs N3 | 0.870 (0.460–1.645) | 0.338 |
| N0 vs Nx | 0.893 (0.378–2.112) | 0.291 |
| Surgery | <0.001 | |
| No cancer-direct surgery versus endoscopic surgery | 1.554 (0.824–2.929) | 0.472 |
| No cancer-direct surgery versus partial gastrectomy | 0.238 (0.121–0.469) | 0.044 |
| No cancer-direct surgery versus total gastrectomy | 0.295 (0.156–0.559) | 0.015 |
| No cancer-direct surgery versus unknown | 0.380 (0.196–0.739) | 0.101 |
| Lymph node dissection | 0.083 | |
| None vs 1–3 regional lymph nodes removed | 1.321 (0.703–2.480) | 0.593 |
| None vs 4 or more regional lymph nodes removed | 0.955 (0.456–1.996) | 0.276 |
| None versus unknown | 0.653 (0.345–1.235) | 0.788 |
| Chemotherapy (none vs yes) | 2.105 (1.718–2.581) | 0.132 |
| Radiation (none vs yes) | 2.172 (1.682–2.803) | 0.597 |
| Size | 0.010 | |
| Invisible to the naked eyes vs ≤1 cm | 0.049 (0.007–0.350) | 0.025 |
| Invisible to the naked eyes vs 1–2 cm | 0.204 (0.158–0.264) | 0.003 |
| Invisible to the naked eyes vs 2–3 cm | 0.318 (0.244–0.415) | 0.018 |
| Invisible to the naked eyes vs 3–4 cm | 0.483 (0.358–0.652) | 0.426 |
| Invisible to the naked eyes vs 4–5 cm | 0.679 (0.490–0.939) | 0.917 |
| Invisible to the naked eyes vs >5 cm or widespread | 0.623 (0.413–0.941) | 0.352 |
| Invisible to the naked eyes versus unknown | 0.804 (0.570–1.134) | 0.682 |
| Marital | <0.001 | |
| Married versus divorced | 0.811 (0.555–1.186) | 0.180 |
| Married versus separated | 1.096 (0.687–1.747) | 0.018 |
| Married versus widowed | 1.725 (0.843–3.530) | 0.001 |
| Married versus single | 1.945 (1.306–2.896) | <0.001 |
| Married versus unknown | 0.863 (0.557–1.338) | 0.100 |