Table 2

Changes from baseline in exenatide-treated and insulin-treated groups (52 weeks)

	Exenatide group			Insulin group
	Normal N=17	Overweight and obese N=10	P value	Normal N=15	Overweight and obese N=17	P value
HbA1c, %	−1.25±1.43	−1.42±1.48	0.772	−1.45±1.06	−0.78±1.66	0.194
FPG, mmol/L	−0.68±3.61	−0.798±3.35	0.941	−3.47±2.95	−1.44±3.58	0.097
eGFR, mL/min/1.73 m²	2.64±6.72	−2.91±4.99	0.044*	−3.79±6.50	−4.69±7.74	0.741
BMI, kg/m²	−0.33±1.93	−1.00±1.05	0.325	1.14±1.00	0.0071±0.83	0.0015*
SBP, mm Hg	−1.18±13.87	−3.00±15.85	0.763	4.67±15.22	0.12±21.63	0.501
DBP, mm Hg	−4.71±11.52	−3.50±12.48	0.802	1.33±10.77	−5.18±9.38	0.083
TBIL, mmol/L	0.21±4.11	2.21±3.43	0.225	−0.50±3.39	−0.15±3.14	0.765
DBIL, mmol/L	0.35±1.49	0.74±1.36	0.527	−0.033±1.04	0.25±1.04	0.460
TG, mmol/L	−0.38±1.76	0.17±0.85	0.293	−0.10±1.42	−0.071±1.71	0.952
TC, mmol/L	−0.47±1.42	0.007±0.67	0.252	−0.025±1.13	−0.089±1.00	0.870
LDL, mmol/L	−0.42±0.93	−0.27±0.67	0.677	−0.04±0.97	−0.26±0.79	0.482
HDL, mmol/L	0.054±0.15	−0.013±0.19	0.321	0.021±0.16	−0.028±0.14	0.387
FIB, g/L	0.34±0.52	0.37±0.31	0.862	0.42±0.42	0.53±0.54	0.544
Irisin, pg/mL	25.88±9.87	26.19±4.03	0.925	25.79±8.31	23.74±9.46	0.601
8-oxo-Gsn, ng/mL	−2.49±0.79	−2.40±0.69	0.799	−1.95±0.88	−2.06±0.59	0.764
NT-proBNP, pg/mL	−109.7±44.38	−91.18±25.67	0.323	−83.27±26.15	−85.21±31.57	0.872
IMT, mm	0.0062±0.25	−0.12±0.22	0.215	0.041±0.15	0.00059±0.27	0.615

*P<0.05.
BMI, body mass index; DBIL, direct bilirubin; DBIL, direct bilirubin; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FIB, fibrinogen; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NT-proBNP, N-terminal pro-brain natriuretie peptide; 8-oxo-Gsn, 8-oxo-7,8-dihydroguanosine; TC, total cholesterol; TG, triglyceride.