Characteristic | All patients | Mild group | Severe group | ||||||
n | Results | % | n | Results | % | n | Results | % | |
Demographic | |||||||||
Age (y, median) | 30 | 31 | 20 | 30.5 | 10 | 31 | |||
Gender | 30 | 20 | 10 | ||||||
Male | 15 | 50 | 9 | 45 | 6 | 60 | |||
Female | 15 | 50 | 11 | 55 | 4 | 40 | |||
Sickle cell disease genotype | 30 | 20 | 10 | ||||||
HbSS | 22 | 73 | 15 | 75 | 7 | 70 | |||
HbSC | 7 | 23 | 4 | 20 | 3 | 30 | |||
HbS-beta zero thalassemia | 1 | 3 | 1 | 5 | 0 | 0 | |||
Medical history | |||||||||
Acute chest syndrome | 30 | 8 | 27 | 20 | 3 | 15 | 10 | 5 | 50 |
Vaso-occlusive crisis | 30 | 11 | 37 | 20 | 8 | 40 | 10 | 3 | 30 |
Avascular necrosis | 30 | 9 | 30 | 20 | 6 | 30 | 10 | 3 | 30 |
Comorbidities | |||||||||
Stroke | 30 | 2 | 7 | 20 | 1 | 5 | 10 | 1 | 10 |
Pulmonary hypertension | 30 | 19 | 63 | 20 | 13 | 65 | 10 | 6 | 60 |
Proteinuria | 30 | 6 | 20 | 20 | 5 | 25 | 10 | 1 | 10 |
Pneumonia | 30 | 7 | 23 | 20 | 5 | 25 | 10 | 2 | 20 |
CKD | 30 | 1 | 3 | 20 | 1 | 5 | 10 | 0 | 0 |
BMI>30 | 30 | 3 | 10 | 20 | 3 | 15 | 10 | 0 | 0 |
Congestive heart failure | 30 | 0 | 0 | 20 | 0 | 0 | 10 | 0 | 0 |
SCD medications | |||||||||
Hydroxyurea | 30 | 23 | 74 | 20 | 17 | 85 | 10 | 6 | 60 |
L-glutamine | 30 | 1 | 3 | 20 | 0 | 0 | 10 | 1 | 10 |
BMI, body mass index; CKD, chronic kidney disease; SCD, sickle cell disease.