Table 1

Comparison between survivors and non-survivors with regard to clinical and laboratory parameters

All patients
N=300
Survivors
n=172
Non-survivors
n=128
P value
Age (years), median (IQR)58.0 (46.0–66.8)55.0 (43.3–66.0)60.0 (49.0–70.0)0.26
Male/female, n180/12092/8088/400.008
Comorbidities, n (%)
 Obesity66 (22.0)22 (12.8)44 (25.6)<0.001
 Hypertension116 (38.7)46 (26.7)70 (40.7)<0.001
 Diabetes mellitus132 (44.0)78 (45.4)54 (31.4)0.59
 Ischemic heart disease46 (15.3)24 (14.0)22 (12.8)0.44
 Liver cirrhosis32 (10.7)14 (8.1)18 (10.5)0.1
 Venous thromboembolism65 (21.7)17 (9.9)48 (37.5)<0.001
Complete blood count, median (IQR)
 Hb (g/L)130.0 (120.0–140.0)130.0 (120.0–140.0)130.0 (115.0–140.0)0.36
 WCC (×109/mL)6.6 (4.3–10.0)6.6 (5.0–10.0)6.7 (3.9–12.0)0.9
 Platelets (×109/mL)209.0 (169.0–250.0)220.0 (183.3–259.0)189.0 (131.5–223.0)<0.001
Inflammatory markers, median (IQR)
 CRP (mg/dL)88.5 (47.3–130.0)52.0 (35.0–82.3)127.5 (97.3–173.0)<0.001
 Procalcitonin (µg/L)0.2 (0.1–0.2)0.1 (0.08–0.2)0.2 (0.1–0.5)0.002
 LDH (U/L)603.5 (410.3–913.0)448.5 (367.3–598.0)911.5 (713.5–1289.8)<0.001
 Ferritin (µg/L)679.0 (419.5–1322.8)518.5 (348.5–667.0)1318.5 (858.3–1925.0)<0.001
Coagulation profile, median (IQR)
 PT (s)14.3 (13.3–16.0)13.3 (13.0–14.5)16.0 (14.8–17.3)<0.001
 APTT (s)35.0 (31.0–44.0)32.0 (30.0–36.0)43.0 (36.0–50.0)<0.001
 D-dimer (ng/mL)1000.0 (740.0–2083.3)790.0 (689.0–942.8)2178.5 (1370.0–3288.5)<0.001
 Fibrinogen (g/dL)3.8 (3.2–5.1)3.2 (3.0–3.7)5.2 (4.5–5.5)<0.001
Complement protein, median (IQR)
 C3 (mg/dL)119.0 (98.0–129.0)128.5 (116.3–141.0)98.0 (70.0–112.8)<0.001
 C3a (ng/mL)272.5 (195.3–363.8)203.0 (170.3–244.0)385.0 (293.0–424.8)<0.001
 C4 (mg/dL)33.0 (29.0–41.0)36.0 (30.0–42.0)31.0 (26.0–35.0)<0.001
 sC5b-9 (ng/mL)318.0 (286.3–389.0)294.0 (242.0–318.8)393.0 (342.0–436.5)<0.001
Other laboratory data, median (IQR)
 Creatinine (mg/dL)1.0 (0.9–1.3)0.9 (0.8–1.1)1.2 (1.1–1.6)<0.001
 Urea (mg/dL)51.0 (39.0–80.0)43.0 (35.0–55.8)72.5 (53.0–94.8)<0.001
 Albumin (g/dL)3.5 (3.1–3.9)3.7 (3.5–4.0)3.2 (2.9–3.5)<0.001
 AST (U/L)47.0 (32.0–75.0)41.0 (27.0–55.0)68.0 (42.0–92.8)<0.001
 ALT (U/L)56.0 (36.0–84.0)46.0 (33.0–61.0)76.0 (51.0–106.0)<0.001
O2 saturation (%), median (IQR)80.0 (70.0–85.0)84.0 (80.0–86.0)70.0 (60.0–80.0)<0.001
O2 support, n (%)
 Mask reservoir142 (47.3)140 (81.4)2 (1.6)<0.001
 Face mask28 (9.3)28 (16.3)
 Invasive130 (43.3)4 (2.3)126 (98.4)
Hospital stay (days), median (IQR)10.0 (7.0–13.0)9.0 (7.0–12.0)10.5 (8.0–14.0)0.047
ICU admission, n (%)130 (43.3)4 (2.3)126 (98.4)<0.001
  • ALT, alanine aminotransferase; APTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CRP, C reactive protein; Hb, hemoglobin; ICU, intensive care unit; LDH, lactate dehydrogenase; O2, oxygen; PT, prothrombin time; WCC, white cell count.