Univariate analysis of patients with early stage gastric cancer
| Variables | HR (95% CI) | P value |
| Statistically significant factors | ||
| Age at diagnosis (years) | <0.001 | |
| ≤40 vs 41–50 | 0.048 (0.019 to 0.122) | <0.001 |
| ≤40 vs 51–60 | 0.086 (0.050 to 0.147) | <0.001 |
| ≤40 vs 61–70 | 0.110 (0.073 to 0.166) | <0.001 |
| ≤40 vs 71–80 | 0.133 (0.091 to 0.195) | <0.001 |
| ≤40 vs 81–90 | 0.213 (0.148 to 0.305) | <0.001 |
| ≤40 vs 91–100 | 0.462 (0.322 to 0.663) | <0.001 |
| Race | 0.097 | |
| White versus black | 1.169 (0.938 to 1.456) | 0.165 |
| White versus other | 1.363 (1.028 to 1.807) | 0.031 |
| Gender (male vs female) | 0.690 (0.579 to 0.823) | <0.001 |
| Location | 0.488 | |
| Fundus versus body | 1.260 (0.864 to 1.838) | 0.230 |
| Fundus versus antrum | 1.023 (0.753 to 1.389) | 0.886 |
| Fundus versus pylorus | 1.129 (0.862 to 1.479) | 0.379 |
| Fundus versus lesser curvature | 1.018 (0.555 to 1.869) | 0.953 |
| Fundus versus greater curvature | 1.107 (0.793 to 1.546) | 0.551 |
| Fundus versus overlapping | 1.210 (0.816 to 1.794) | 0.344 |
| Fundus versus NOS | 1.539 (1.045 to 2.266) | 0.029 |
| Histology | <0.001 | |
| Adenocarcinoma versus signet ring cell carcinoma | 3.039 (2.054 to 4.496) | <0.001 |
| Adenocarcinoma versus special type | 2.122 (1.365 to 3.297) | 0.001 |
| Adenocarcinoma versus unknown | 0.866 (0.515 to 1.457) | 0.588 |
| Adenocarcinoma versus other | 2.893 (1.733 to 4.829) | <0.001 |
| Grade | <0.001 | |
| Well differentiated versus moderately differentiated | 0.618 (0.457 to 0.836) | 0.002 |
| Well differentiated versus undifferentiated | 1.450 (1.139 to 1.846) | 0.003 |
| Well differentiated versus unknown | 1.027 (0.807 to 1.306) | 0.828 |
| Stage_T | 0.012 | |
| T1a versus T1b | 0.731 (0.592 to 0.903) | 0.004 |
| T1a versus T1NOS | 0.829 (0.673 to 1.020) | 0.077 |
| Stage_N | <0.001 | |
| N0 vs N1 | 0.550 (0.351 to 0.861) | 0.009 |
| N0 vs N2 | 0.962 (0.576 to 1.608) | 0.884 |
| N0 vs N3 | 0.870 (0.460 to 1.645) | 0.668 |
| N0 vs Nx | 0.893 (0.378 to 2.112) | 0.797 |
| Surgery | <0.001 | |
| No cancer-direct surgery versus endoscopic surgery | 1.554 (0.824 to 2.929) | 0.173 |
| No cancer-direct surgery versus partial gastrectomy | 0.238 (0.121 to 0.469) | <0.001 |
| No cancer-direct surgery versus total gastrectomy | 0.295 (0.156 to 0.559) | <0.001 |
| No cancer-direct surgery versus unknown | 0.380 (0.196 to 0.739) | 0.004 |
| Lymph node dissection | <0.001 | |
| None vs 1–3 regional lymph nodes removed | 1.321 (0.703 to 2.480) | 0.387 |
| None vs 4 or more regional lymph nodes removed | 0.955 (0.456 to 1.996) | 0.902 |
| None versus unknown | 0.653 (0.345 to 1.235) | 0.190 |
| Chemotherapy (none vs yes) | 2.105 (1.718 to 2.581) | <0.001 |
| Radiation (none vs yes) | 2.172 (1.682 to 2.803) | <0.001 |
| Size | <0.001 | |
| Invisible to the naked eyes vs ≤1 cm | 0.049 (0.007 to 0.350) | 0.003 |
| Invisible to the naked eyes vs 1–2 cm | 0.204 (0.158 to 0.264) | <0.001 |
| Invisible to the naked eyes vs 2–3 cm | 0.318 (0.244 to 0.415) | <0.001 |
| Invisible to the naked eyes vs 3–4 cm | 0.483 (0.358 to 0.652) | <0.001 |
| Invisible to the naked eyes vs 4–5 cm | 0.679 (0.490 to 0.939) | 0.019 |
| Invisible to the naked eyes vs >5 cm or widespread | 0.623 (0.413 to 0.941) | 0.024 |
| Invisible to the naked eyes versus unknown | 0.804 (0.570 to 1.134) | 0.214 |
| Insurance | 0.626 | |
| Insured versus uninsured | 0.799 (0.505 to 1.264) | 0.338 |
| Insured versus unknown | 0.776 (0.377 to 1.599) | 0.492 |
| Marital | <0.001 | |
| Married versus divorced | 0.811 (0.555 to 1.186) | 0.280 |
| Married versus separated | 1.096 (0.687 to 1.747) | 0.701 |
| Married versus widowed | 1.725 (0.843 to 3.530) | 0.136 |
| Married versus single | 1.945 (1.306 to 2.896) | 0.001 |
| Married versus unknown | 0.863 (0.557 to 1.338) | 0.511 |
NOS, not otherwise specified.