Baseline symptom scores by CKD status
| Variable description, median (IQR) | Non-CKD N=8 | CKD N=13 | P value |
| Dyspnea* | 0.0 (0.0–2.4) | 1.0 (0.0–5.0) | 0.39 |
| Fatigue† | 24.0 (18.0–43.0) | 28.0 (24.0–43.0) | 0.38 |
| Depression‡ | 6.0 (3.0–12.5) | 8.0 (3.5–13.0) | 0.49 |
| Quality of life§ | |||
| Symptom burden | 73.9 (57.8–90.3) | 65.9 (52.3–77.3) | 0.29 |
| Effect of CKD | 98.4 (73.4–100.0) | 93.8 (53.1–100.0) | 0.30 |
| Burden of CKD | 100.0 (70.3–100.0) | 75 (21.9–84.4) | 0.05 |
| Work | 50.0 (0.0–100.0) | 50.0 (0.0–100.0) | 0.70 |
| Cognitive function | 76.7 (53.3–96.7) | 80.0 (26.7–93.3) | 0.51 |
| Social | 73.3 (51.7–86.7) | 66.7 (36.7–93.3) | 0.94 |
| Sex | 37.5 (28.1–84.4) | 93.8 (40.6–100.0) | 0.45 |
| Sleep | 66.3 (40.6–71.9) | 57.5 (37.5–72.5) | 0.66 |
| Social support | 66.7 (33.3–83.3) | 50.0 (41.7–100.0) | 0.80 |
| Physical functioning | 42.5 (22.5–83.8) | 45.0 (17.5–70.0) | 0.80 |
| Role physical | 12.5 (0.0–93.8) | 0.0 (0.0–100.0) | 1.00 |
| Pain | 45.0 (22.5–56.9) | 32.5 (22.5–67.5) | 0.94 |
| General health | 47.5 (36.3–67.5) | 30.0 (22.5–57.5) | 0.17 |
| Emotional | 69.0 (57.0–82.0) | 64.0 (44.0–86.0) | 0.54 |
| Role emotional | 66.7 (0.0–100.0) | 66.7 (0.0–100.0) | 0.69 |
| Social functioning | 50.0 (50.0–87.5) | 50.0 (37.5–100.0) | 0.80 |
| Fatigue | 37.5 (16.2–67.5) | 40.0 (30.0–72.5) | 0.47 |
*Measured using the dyspnea visual analog scale, range 0–10. Higher scores indicate more severe dyspnea.
†Measured using the Functional Assessment of Chronic Illness Therapy-Fatigue, range 0–52. Higher scores indicate less severe fatigue.
‡Measured using the 16-item Self-Reported Quick Inventory of Depressive Symptomatology, range 0–48. Higher scores indicate more severe depression.
§Measured using the Kidney Disease Health Related Quality of Life-Short Form 36, range 0–100. Higher scores indicate more favorable quality of life.