Relation between uremic pruritus severity and the clinical and laboratory data
| Mild n=75 | Moderate/severe n=76 | P value | |
| Age (y), mean±SD | 51.9±15.6 | 53.0±12.7 | 0.54 |
| Male/female, n | 42/33 | 49/27 | 0.29 |
| HD duration (y), median (IQR) | 3.0 (1.0–5.0) | 4.0 (2.0–10.0) | 0.002 |
| History/comorbidities, n (%) | |||
| History of allergy | 5 (6.7) | 12 (15.8) | 0.08 |
| Hypertension | 61 (81.3) | 55 (72.4) | 0.19 |
| Diabetes mellitus | 14 (18.7) | 18 (23.7) | 0.45 |
| HCV | 28 (37.3) | 31 (40.8) | 0.66 |
| Used medications, n (%) | |||
| Calcimate | 65 (86.7) | 63 (82.9) | 0.52 |
| Cinacalcet | 5 (6.7) | 6 (7.9) | 0.77 |
| Vitamin D | 14 (18.7) | 5 (6.6) | 0.03 |
| Analgesics | 12 (16.0) | 5 (6.6) | 0.07 |
| Antihypertensives | |||
| Beta blockers | 42 (56.0) | 46 (60.5) | 0.57 |
| Calcium channel blockers | 41 (54.7) | 35 (46.1) | 0.25 |
| ACE inhibitors | 33 (44.0) | 32 (42.1) | 0.81 |
| Vasodilators | 30 (40.0) | 22 (29.0) | 0.15 |
| Clonidine | 5 (6.7) | 3 (4.0) | 0.46 |
| Hemodialysis parameters, mean±SD | |||
| Frequency (session/wk) | 2.9±0.5 | 2.9±0.3 | 0.95 |
| Duration of session (h) | 3.9±0.5 | 3.9±0.4 | 0.46 |
| Ultrafiltration volume (L) | 2.1±0.8 | 2.4±1.0 | 0.06 |
| Pump flow rate (mL/min) | 267.9±38.1 | 262.1±36.5 | 0.33 |
| Kt/V | 1.3±0.14 | 1.31±0.15 | 0.88 |
| Dry weight (kg) | 66.5±5.5 | 66.9±6.2 | 0.7 |
| Intradialytic weight gain (kg) | 2.4±0.6 | 2.7±0.5 | 0.68 |
| Laboratory findings, mean±SD/median (IQR) | |||
| Hb (g/L) | 10.1±1.9 | 10.1±2.1 | 0.88 |
| Creatinine (mg/dL) | 8.7±3.4 | 8.6±2.8 | 0.87 |
| Urea (mg/dL) | 121.7±43.9 | 103.4±49.6 | 0.17 |
| Albumin (g/dL) | 4.0±0.6 | 3.7±0.5 | 0.01 |
| Calcium (mg/dL) | 9.1±1.2 | 9.0±1.2 | 0.38 |
| Phosphorus (mg/dL) | 5.5±1.9 | 5.8±1.9 | 0.28 |
| PTH (pg/mL) | 645.9 (423.7–962.9) | 683.5 (446.0–1287.6) | 0.72 |
| AST (U/L) | 4.5±2.3 | 4.4±2.2 | 0.87 |
| ALT (U/L) | 20.7±17.9 | 20.1±12.6 | 0.83 |
| Uric acid (mg/dL) | 4.6±2.0 | 4.4±2.4 | 0.93 |
| Ferritin (ng/mL) | 455.0 (325.5–1109.3) | 526.0 (372.0–965.0) | 0.48 |
| hsCRP (mg/L) | 108.0±38.2 | 121.6±29.5 | 0.02 |
ALT, alanine transferase; AST, aspartate transferase; HCV, hepatitis C virus; HD, hemodialysis; hsCRP, high-sensitivity C-reactive protein; PTH, parathyroid hormone.