Levels of biomarkers of oxidative stress in patients with leukemia compared with healthy individuals
| Variables | ALL (n=72) | Control (n=72) | P value | AML (n=37) | Control (n=37) | P value |
| Mean±SD | Mean±SD | Mean±SD | Mean±SD | |||
| SOD (U/mL) | 40.47±15.42 | 69.20±19.94 | <0.001* | 37.40±14.45 | 68.95±20.75 | <0.001* |
| GPx (U/L) | 42.05±13.19 | 50.19±10.83 | <0.001* | 45.78±14.12 | 49.58±10.38 | 0.039* |
| CAT (KU/L) | 167.18±30.26 | 166.72±24.26 | 0.919 | 165.59±28.89 | 169.17±22.29 | 0.552 |
| TAC (nmol/Fe2+) | 439.21±104.27 | 676.29±166.25 | <0.001* | 447.21±111.99 | 695.7±166.93 | <0.001* |
| MDA (nmol/mL) | 1.37±0.33 | 1.11±0.51 | <0.001* | 1.32±0.33 | 1.11±0.51 | 0.041* |
| NO (nmol/mL) | 20.04±2.76 | 17.13±1.72 | <0.001* | 19.78±2.82 | 17.36±1.50 | <0.001* |
| PC (nmol/mg protein) | 3.35±0.94 | 2.28±0.59 | <0.001* | 3.36±1.01 | 2.29±0.52 | <0.001* |
| AChE (U/g Hb) | 5.68±1.80 | 6.89±1.22 | <0.001* | 5.99±1.92 | 6.91±0.98 | 0.011* |
| PON1 (U/L) | 58.01±20.94 | 82.93±18.79 | <0.001* | 56.89±20.74 | 84.67±21.26 | <0.001* |
MDA, PC, and NO levels increased significantly, and TAC, SOD, GPx, AChE, and PON1 decreased significantly in patient with leukemia than in healthy individuals (p<0.05). However, no significant change in CAT level was observed between the groups (p>0.05).
*P<0.05.
AChE, acetylcholinesterase; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CAT, catalase; GPx, glutathione peroxidase; MDA, malondialdehyde; NO, nitric oxide; PC, protein carbonyl; PON1, paraoxonase-1; SOD, superoxide dismutase; TAC, total antioxidant capacity.