Press, 2015 | Parent Survey | 75 | 3 weeks to 18 years | 57% some improvements; 33% had greater than 50% reduction in seizures; 0.3% had seizure freedom | Not given | None Reported | 44% including increased seizures (13%) and somnolence/fatigue (12%) | Less than 6 months | 5.6 months |
Porter, 2013 | Parent Survey | 19 | 2 to 16 years | 84% seizure reduction; 11% complete seizure freedom; 42% had >80% seizure reduction | 0.5–28.6 mg/kg/day | 63% tried an average of 12 other antiepileptic drugs before using cannabis. 95% experienced treatment-resistant epilepsy for more than 3 years before trying cannabis. | 37% drowsiness and 16% fatigue | None | Average 4 months to see results |
Hussain, 2015 | Parent Survey | 117 | 5.5 months to 18 years | 85% had reduction in seizure; 14% had complete seizure freedom | 2.9–7.5 mg/kg/day | 8 failed medications prior to CBD exposure | 12.8% drowsiness, 29.9% increased appetite and 9.4% fatigue | None | Changes in seizure frequency were typically observed after 2 weeks |
Maa, 2014 | Case Report | 1 | Started at 3 months end of study | Seizures reduced down to 2–3 nocturnal seizures per month | 4 mg/lb per day | Was on clobazam but proved not effective | None Reported | Reported improved behavior daily | 20 months |
Saade, 2015 | Case Report | 1 | Started at 39 weeks until 10 months | Seizures decreased from 10–20 per day to up to 9 days with no clinical seizures | 25 mg/kg/day | Phenobarbital, levetiracetam, carbamazepine,clonazepam,fosphenytoin. topiramate | None Reported | Improvements seen and noted daily | 10 months |