Regular ArticleMolecular Cloning, Structural Characterization, and Chromosomal Mapping of the Human LECT2 Gene☆
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Cited by (43)
Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2)
2021, Journal of Biological ChemistryGenomic and functional characterization of the lect2 gene from Siniperca chuatsi
2020, Fish and Shellfish ImmunologyCitation Excerpt :The Sc-lect2 gene consists of four exons and three introns, similar to the lect2 genes of L. calcarifer [21], Mus. musculus [35], and H. sapiens [15] but different from the lect2 genes of C. idella [36] and D. rerio [16], which consist of five exons and four introns. This finding indicates that the genes show some diversity over the course of teleost evolution [37].
Delving into the amyloidogenic core of human leukocyte chemotactic factor 2
2019, Journal of Structural BiologyLeukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States
2014, BloodCitation Excerpt :Recognition of the characteristic globular pattern of ALect2 amyloid deposition helps one to consider ALect2 amyloidosis in the differential diagnosis of hepatic amyloidosis because it contrasts distinctly with the perisinusoidal amyloid deposition pattern that typifies hepatic AL amyloidosis. LECT2 is synthesized principally by the liver, and is secreted by hepatoma cell lines.16-19 LECT2 serum levels are elevated in hepatic disorders.20-22
Identification and expression analysis of the leukocyte cell-derived chemotaxin-2 (LECT2) gene in duck (Anas platyrhynchos)
2014, GeneCitation Excerpt :Leukocyte cell-derived chemotaxin 2 (LECT2), discovered in 1996, is a chemotactic factor for neutrophils (Yamagoe et al., 1996). Human LECT2 is a 16-kDa basic protein with three intramolecular disulphide bonds; it is expressed in the liver and secreted into the bloodstream (Yamagoe et al., 1998a). LECT2 also plays a role in such disparate processes as the regulation of liver regeneration (Sato et al., 2004a, 2004b), carcinogenesis (Ong et al., 2011; Ovejero et al., 2004; Uchida et al., 1999), hepatic injury (Segawa et al., 2001), and natural killer T (NKT) cell homeostasis (Saito et al., 2004).
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Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under Accession No. AB007546.
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