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Preterm Birth and Hypertension: Is There a Link?

  • Pathogenesis of Hypertension (W Elliott and R Santos, Section Editors)
  • Published:
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Abstract

Factors in perinatal life have recently been recognized as determinants of later life health and diseases, especially hypertension. The detection of higher values of blood pressure in preterm-born individuals reaching adulthood has turned the attention to preterm birth-related complications and deleterious conditions as factors triggering early cardiovascular alterations, which may increase hypertension risk and associated complications in this population. Further, preterm birth is frequently associated with pregnancy complications such as lower placental perfusion, increased blood pressure in the mother and preeclampsia, often resulting in intrauterine growth restriction. These conditions further impact the risk of hypertension in the offspring whether through inherited genetic factors or perpetuated pathophysiology leading to preeclampsia, preterm delivery, and chronic hypertension. In this review, we will highlight evidence of developmental cardiovascular alterations and potential mechanisms linking preterm birth to the risk of hypertension and cardiovascular diseases into adulthood.

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Acknowledgments

We thank Fauve Boudreau for the illustration.

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Authors and Affiliations

  1. Department of Pediatrics, Sainte-Justine University Hospital Research Center, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada

    Mariane Bertagnolli, Thuy Mai Luu & Anne Monique Nuyt

  2. Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK

    Adam James Lewandowski & Paul Leeson

  3. Division of Neonatology, Department of Pediatrics, Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, H3T 1C5, Montréal, Québec, Canada

    Anne Monique Nuyt

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  1. Mariane Bertagnolli
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  2. Thuy Mai Luu
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  3. Adam James Lewandowski
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  4. Paul Leeson
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Correspondence to Anne Monique Nuyt.

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Conflict of Interest

Dr. Luu reports grants from Merck Sharpe & Dohme. Dr. Leeson reports grants from the British Heart Foundation and Wellcome Trust. Drs. Bertagnolli, Lewandowski, and Nuyt declare no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Pathogenesis of Hypertension

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Bertagnolli, M., Luu, T.M., Lewandowski, A.J. et al. Preterm Birth and Hypertension: Is There a Link?. Curr Hypertens Rep 18, 28 (2016). https://doi.org/10.1007/s11906-016-0637-6

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  • DOI: https://doi.org/10.1007/s11906-016-0637-6

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