Clinical studyPrimary pulmonary hypertension: I. Clinical and hemodynamic study☆
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2022, Cardiology ClinicsCitation Excerpt :Pulmonary arterial hypertension (PAH) was first suspected in 1891 when Dr E. Romberg reported a case of a patient with pulmonary artery thickening without other heart or lung disease findings on autopsy. Later in 1951, Dr D.T. Dresdale described an additional series of 3 patients and named the condition primary pulmonary hypertension.1 Since then, the understanding and characterization of PAH have evolved with multiple etiologies identified and categorized into 5 groups by the 2018 6th World Symposium of Pulmonary Hypertension (Table 1).
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2021, Clinics in Chest MedicineCitation Excerpt :He noted that in the hemodynamic studies of the patients he presented, “All had greatly elevated pulmonary artery pressures, elevated RV end diastolic pressure, diminished cardiac outputs… [and] a seven-to nine-fold increase in pulmonary resistance.” He was able to perform dynamic studies on animal models, wherein he elicited acute pulmonary vasoconstriction via hypoxemia and mitigated these effects with the pulmonary vasodilator tolazoline.11 Despite the progressive steps taken toward insight into this new disease, it took a crisis to raise the urgency of the medical community to come together and quickly advance its understanding and approach to pulmonary hypertension.
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This investigation was supported in part by a research grant from the National Heart Institute of the National Institutes of Health, Public Health Service.
- 1
From the Medical Service, Maimonides Hospital of Brooklyn and the Department of Medicine, State University of New York at New York City, College of Medicine.